Toxicity of three types of arsenolipids: species-specific effects in Caenorhabditis elegans

Julia Bornhorst; Franziska Ebert; Sören Meyer; Vanessa Ziemann; Chan Xiong; Nikolaus Guttenberger; Andrea Raab; Jessica Baesler; Michael Aschner; Jörg Feldmann; Kevin Francesconi; Georg Raber; Tanja Schwerdtle

doi:10.1039/d0mt00039f

Toxicity of three types of arsenolipids: species-specific effects in Caenorhabditis elegans

Julia Bornhorst, Franziska Ebert, Sören Meyer, Vanessa Ziemann, Chan Xiong, Nikolaus Guttenberger, Andrea Raab, Jessica Baesler, Michael Aschner, Jörg Feldmann, Kevin Francesconi, Georg Raber, Tanja Schwerdtle^* (Corresponding Author)

^*Corresponding author for this work

Chemistry

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Abstract

Although fish and seafood are well known for their nutritional benefits, they contain contaminants that might affect human health. Organic lipid-soluble arsenic species, so called arsenolipids, belong to the emerging contaminants in these food items; their toxicity has yet to be systematically studied. Here, we apply the in vivo model Caenorhabditis elegans to assess the effects of two arsenic-containing hydrocarbons (AsHC), a saturated arsenic-containing fatty acid (AsFA), and an arsenic-containing triacylglyceride (AsTAG) in a whole organism. Although all arsenolipids were highly bioavailable in Caenorhabditis elegans, only the AsHCs were substantially metabolized to thioxylated or shortened metabolic products and induced significant toxicity, affecting both survival and development. Furthermore, the AsHCs were several fold more potent as compared to the toxic reference arsenite. This study clearly indicates the need for a full hazard identification of subclasses of arsenolipids to assess whether they pose a risk to human health.

Original language	English
Pages (from-to)	794-798
Number of pages	5
Journal	Metallomics
Volume	12
Issue number	5
Early online date	23 Mar 2020
DOIs	https://doi.org/10.1039/d0mt00039f
Publication status	Published - 27 May 2020

Bibliographical note

This work was supported by the German Research Foundation (DFG), grant number SCHW 903/10-1 and the Austrian Science Fund (FWF), project number I2412-B21. MA was supported in part by grants from the NIEHS, R01ES10563 and R0107331.

Keywords

ARSENIC-CONTAINING HYDROCARBONS
VITRO TOXICOLOGICAL CHARACTERIZATION
CONTAINING FATTY-ACIDS
MODEL
FISH
METABOLISM
BRAIN
OIL

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Bornhorst_etal_Metabolomics_Toxicity_AAMAccepted author manuscript, 276 KBLicence: Other

Cite this

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title = "Toxicity of three types of arsenolipids: species-specific effects in Caenorhabditis elegans",

abstract = "Although fish and seafood are well known for their nutritional benefits, they contain contaminants that might affect human health. Organic lipid-soluble arsenic species, so called arsenolipids, belong to the emerging contaminants in these food items; their toxicity has yet to be systematically studied. Here, we apply the in vivo model Caenorhabditis elegans to assess the effects of two arsenic-containing hydrocarbons (AsHC), a saturated arsenic-containing fatty acid (AsFA), and an arsenic-containing triacylglyceride (AsTAG) in a whole organism. Although all arsenolipids were highly bioavailable in Caenorhabditis elegans, only the AsHCs were substantially metabolized to thioxylated or shortened metabolic products and induced significant toxicity, affecting both survival and development. Furthermore, the AsHCs were several fold more potent as compared to the toxic reference arsenite. This study clearly indicates the need for a full hazard identification of subclasses of arsenolipids to assess whether they pose a risk to human health.",

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AU - Bornhorst, Julia

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AU - Meyer, Sören

AU - Ziemann, Vanessa

AU - Xiong, Chan

AU - Guttenberger, Nikolaus

AU - Raab, Andrea

AU - Baesler, Jessica

AU - Aschner, Michael

AU - Feldmann, Jörg

AU - Francesconi, Kevin

AU - Raber, Georg

AU - Schwerdtle, Tanja

N1 - This work was supported by the German Research Foundation (DFG), grant number SCHW 903/10-1 and the Austrian Science Fund (FWF), project number I2412-B21. MA was supported in part by grants from the NIEHS, R01ES10563 and R0107331.

PY - 2020/5/27

Y1 - 2020/5/27

N2 - Although fish and seafood are well known for their nutritional benefits, they contain contaminants that might affect human health. Organic lipid-soluble arsenic species, so called arsenolipids, belong to the emerging contaminants in these food items; their toxicity has yet to be systematically studied. Here, we apply the in vivo model Caenorhabditis elegans to assess the effects of two arsenic-containing hydrocarbons (AsHC), a saturated arsenic-containing fatty acid (AsFA), and an arsenic-containing triacylglyceride (AsTAG) in a whole organism. Although all arsenolipids were highly bioavailable in Caenorhabditis elegans, only the AsHCs were substantially metabolized to thioxylated or shortened metabolic products and induced significant toxicity, affecting both survival and development. Furthermore, the AsHCs were several fold more potent as compared to the toxic reference arsenite. This study clearly indicates the need for a full hazard identification of subclasses of arsenolipids to assess whether they pose a risk to human health.

AB - Although fish and seafood are well known for their nutritional benefits, they contain contaminants that might affect human health. Organic lipid-soluble arsenic species, so called arsenolipids, belong to the emerging contaminants in these food items; their toxicity has yet to be systematically studied. Here, we apply the in vivo model Caenorhabditis elegans to assess the effects of two arsenic-containing hydrocarbons (AsHC), a saturated arsenic-containing fatty acid (AsFA), and an arsenic-containing triacylglyceride (AsTAG) in a whole organism. Although all arsenolipids were highly bioavailable in Caenorhabditis elegans, only the AsHCs were substantially metabolized to thioxylated or shortened metabolic products and induced significant toxicity, affecting both survival and development. Furthermore, the AsHCs were several fold more potent as compared to the toxic reference arsenite. This study clearly indicates the need for a full hazard identification of subclasses of arsenolipids to assess whether they pose a risk to human health.

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Toxicity of three types of arsenolipids: species-specific effects in Caenorhabditis elegans

Abstract

Bibliographical note

Keywords

UN SDGs

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