Abstract
Histology (H&E) and transmission electron microscopy (TEM) data are provided showing age-related changes in the retinal structure of sTg-IRBP:HEL mice. These include substantial photoreceptor loss, atrophy of the retinal pigment epithelium, Bruch׳s membrane disruption and thickening, along with the presence of drusenoid deposits and changes in basal laminar infoldings. These features resemble some of those key characteristics found in the course of human dry (atrophic) age-related macular degeneration (AMD), particularly with regard to drusen. Hence, we believe the sTg-IRBP:HEL mouse model represents a useful and promising archetype for future study of the mechanism of drusen formation in AMD.
Original language | English |
---|---|
Pages (from-to) | 140-144 |
Number of pages | 5 |
Journal | Data in brief |
Volume | 22 |
Early online date | 6 Dec 2018 |
DOIs | |
Publication status | Published - Feb 2019 |
Bibliographical note
We are grateful to the Microscopy and Histology Core Facility of the University of Aberdeen for their assistance with sample processing. This work was generously funded by the charity Saving Sight in Grampian of the University of Aberdeen Development Trust.Fingerprint
Dive into the research topics of 'Transmission Electron Microscopy Data on drusen-like deposits in the retinal degeneration sTg-IRBP: HEL mouse model'. Together they form a unique fingerprint.Equipment
-
Microscopy and Histology
Wilkinson, D. (Manager) & Milne, G. (Manager)
Medical SciencesResearch Facilities: Facility