Tumour excisional surgery, anaesthetic-analgesic techniques, and oncologic outcomes: a narrative review

Orla Murphy; Patrice Forget; Daqing Ma; Donal J Buggy

doi:10.1016/j.bja.2023.07.027

Tumour excisional surgery, anaesthetic-analgesic techniques, and oncologic outcomes: a narrative review

Orla Murphy, Patrice Forget, Daqing Ma, Donal J Buggy^* (Corresponding Author)

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

Abstract

Cancer is a growing global burden; there were an estimated 18 million new cancer diagnoses worldwide in 2020. Excisional surgery remains one of the main treatments for solid organ tumours in cancer patients and is potentially curative. Cancer- and surgery-induced inflammatory processes can facilitate residual tumour cell survival, growth, and subsequent recurrence. However, it has been hypothesised that anaesthetic and analgesic techniques during surgery might influence the risk of cancer recurrence. This narrative review aims to provide an updated summary of recent observational studies and new randomised controlled clinical trials on whether certain specific anaesthetic and analgesic techniques or perioperative interventions during tumour resection surgery of curative intent materially affect long-term oncologic outcomes.

Original language	English
Pages (from-to)	989-1001
Number of pages	13
Journal	British Journal of Anaesthesia
Volume	131
Issue number	6
Early online date	7 Sept 2023
DOIs	https://doi.org/10.1016/j.bja.2023.07.027
Publication status	Published - 1 Dec 2023

Keywords

general anaesthesia
intravenous anaesthesia
metastasis cancer
opioid cancer
postoperative analgesia
recurrence cancer
regional analgesia
surgery

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Cite this

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title = "Tumour excisional surgery, anaesthetic-analgesic techniques, and oncologic outcomes: a narrative review",

abstract = "Cancer is a growing global burden; there were an estimated 18 million new cancer diagnoses worldwide in 2020. Excisional surgery remains one of the main treatments for solid organ tumours in cancer patients and is potentially curative. Cancer- and surgery-induced inflammatory processes can facilitate residual tumour cell survival, growth, and subsequent recurrence. However, it has been hypothesised that anaesthetic and analgesic techniques during surgery might influence the risk of cancer recurrence. This narrative review aims to provide an updated summary of recent observational studies and new randomised controlled clinical trials on whether certain specific anaesthetic and analgesic techniques or perioperative interventions during tumour resection surgery of curative intent materially affect long-term oncologic outcomes.",

keywords = "general anaesthesia, intravenous anaesthesia, metastasis cancer, opioid cancer, postoperative analgesia, recurrence cancer, regional analgesia, surgery",

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AU - Forget, Patrice

AU - Ma, Daqing

AU - Buggy, Donal J

PY - 2023/12/1

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N2 - Cancer is a growing global burden; there were an estimated 18 million new cancer diagnoses worldwide in 2020. Excisional surgery remains one of the main treatments for solid organ tumours in cancer patients and is potentially curative. Cancer- and surgery-induced inflammatory processes can facilitate residual tumour cell survival, growth, and subsequent recurrence. However, it has been hypothesised that anaesthetic and analgesic techniques during surgery might influence the risk of cancer recurrence. This narrative review aims to provide an updated summary of recent observational studies and new randomised controlled clinical trials on whether certain specific anaesthetic and analgesic techniques or perioperative interventions during tumour resection surgery of curative intent materially affect long-term oncologic outcomes.

AB - Cancer is a growing global burden; there were an estimated 18 million new cancer diagnoses worldwide in 2020. Excisional surgery remains one of the main treatments for solid organ tumours in cancer patients and is potentially curative. Cancer- and surgery-induced inflammatory processes can facilitate residual tumour cell survival, growth, and subsequent recurrence. However, it has been hypothesised that anaesthetic and analgesic techniques during surgery might influence the risk of cancer recurrence. This narrative review aims to provide an updated summary of recent observational studies and new randomised controlled clinical trials on whether certain specific anaesthetic and analgesic techniques or perioperative interventions during tumour resection surgery of curative intent materially affect long-term oncologic outcomes.

KW - general anaesthesia

KW - intravenous anaesthesia

KW - metastasis cancer

KW - opioid cancer

KW - postoperative analgesia

KW - recurrence cancer

KW - regional analgesia

KW - surgery

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DO - 10.1016/j.bja.2023.07.027

M3 - Review article

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ER -

Tumour excisional surgery, anaesthetic-analgesic techniques, and oncologic outcomes: a narrative review

Abstract

Keywords

UN SDGs

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