Tuning of Synaptic Integration in the Medial Entorhinal Cortex to the Organization of Grid Cell Firing Fields

D.L.F. Garden, P.D. Dodson, C. O'Donnell, M.D. White, M.F. Nolan

Research output: Contribution to journalArticlepeer-review

128 Citations (Scopus)


Neurons important for cognitive function are often classified by their morphology and integrative properties. However, it is unclear if within a single class of neuron these properties tune synaptic responses to the salient features of the information that each neuron represents. We demonstrate that for stellate neurons in layer II of the medial entorhinal cortex, the waveform of postsynaptic potentials, the time window for detection of coincident inputs, and responsiveness to gamma frequency inputs follow a dorsal-ventral gradient similar to the topographical organization of grid-like spatial firing fields of neurons in this area. We provide evidence that these differences are due to a membrane conductance gradient mediated by HCN and leak potassium channels. These findings suggest key roles for synaptic integration in computations carried out within the medial entorhinal cortex and imply that tuning of neural information processing by membrane ion channels is important for normal cognitive function.
Original languageEnglish
Pages (from-to)875-889
Issue number5
Early online date10 Dec 2008
Publication statusPublished - 2008

Bibliographical note

Acknowledgements: We thank Mayank Dutia and Stephen Williams for comments on an earlier version of the manuscript, Gareth Leng for statistical advice, and Jessie vanBinsbergen and Michelle Lew for assistance with reconstructions. This work was supported by the Medical Research Council (M.F.N. and C.O'D.), a Marie Curie Excellence grant (M.F.N.), the network of European Neuroscience Institutes (ENI-NET), a Human Frontier Science Program long-term fellowship (P.D.D.), and the EPSRC (C.O'D.).


Dive into the research topics of 'Tuning of Synaptic Integration in the Medial Entorhinal Cortex to the Organization of Grid Cell Firing Fields'. Together they form a unique fingerprint.

Cite this