Twenty-five years of nuclear receptor structure analysis: From the laboratory to the clinic

Iain J. McEwan*, Raj Kumar

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)


High resolution structural analysis of nuclear receptors has been possible for the last twenty-five years. During this period we have moved from a schematic representation of nuclear receptors, based on biochemical studies, to crystal and NMR structures of the isolated ligand binding and DNA binding domains, which have increased our understanding of receptor structure and provided fresh insights into function. Recent progress has seen the emergence of almost complete three-dimensional descriptions for nuclear receptor complexes bound to cognate response elements. These dramatic advances in structural analysis are paralleled by the growing evidence linking nuclear receptor function to normal physiological processes and disease. The insights gained from nuclear receptor structures have the potential to be translated into new drugs for major diseases, including cancer, metabolic syndrome and cardiovascular disease
Original languageEnglish
Title of host publicationNuclear Receptors
Subtitle of host publicationFrom Structure to the Clinic
EditorsIain J McEwan, Raj Kumar
PublisherSpringer International Publishing
Number of pages14
ISBN (Electronic)9783319187297
ISBN (Print)9783319187280
Publication statusPublished - 20 Aug 2015


  • Ligand binding domain
  • DNA binding domain
  • – Amino-terminal domain
  • NMR spectroscopy
  • X-ray crystallography
  • Nuclear receptor superfamily


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