Update of the fracture risk prediction tool FRAX: a systematic review of potential cohorts and analysis plan

L. Vandenput; H. Johansson; E. V. McCloskey; E. Liu; K. E. Åkesson; F. A. Anderson; R. Azagra; C. L. Bager; C. Beaudart; H. A. Bischoff-Ferrari; E. Biver; O. Bruyère; J. A. Cauley; J. R. Center; R. Chapurlat; C. Christiansen; C. Cooper; C. J. Crandall; S. R. Cummings; J. A. P. da Silva; B. Dawson-Hughes; A. Diez-Perez; A. B. Dufour; J. A. Eisman; P. J. M. Elders; S. Ferrari; Y. Fujita; S. Fujiwara; C.-C. Glüer; I. Goldshtein; D. Goltzman; V. Gudnason; J. Hall; D. Hans; M. Hoff; R. J. Hollick; M. Huisman; M. Iki; S. Ish-Shalom; G. Jones; M. K. Karlsson; S. Khosla; D. P. Kiel; W.-P. Koh; F. Koromani; M. A. Kotowicz; H. Kröger; T. Kwok; O. Lamy; D. J. Torgerson; Natasja M. van Schoor; T. P. van Staa; J. Vilà; N. J. Wareham; N. C.  Wright; T. Yoshimura; M. C. Zillikens; Joost J. Zwart; N. Harvey; Mattias Lorentzon; W. D. Leslie; J A  Kanis

doi:10.1007/s00198-022-06435-6

Update of the fracture risk prediction tool FRAX: a systematic review of potential cohorts and analysis plan

L. Vandenput, H. Johansson, E. V. McCloskey, E. Liu, K. E. Åkesson, F. A. Anderson, R. Azagra, C. L. Bager, C. Beaudart, H. A. Bischoff-Ferrari, E. Biver, O. Bruyère, J. A. Cauley, J. R. Center, R. Chapurlat, C. Christiansen, C. Cooper, C. J. Crandall, S. R. Cummings, J. A. P. da SilvaB. Dawson-Hughes, A. Diez-Perez, A. B. Dufour, J. A. Eisman, P. J. M. Elders, S. Ferrari, Y. Fujita, S. Fujiwara, C.-C. Glüer, I. Goldshtein, D. Goltzman, V. Gudnason, J. Hall, D. Hans, M. Hoff, R. J. Hollick, M. Huisman, M. Iki, S. Ish-Shalom, G. Jones, M. K. Karlsson, S. Khosla, D. P. Kiel, W.-P. Koh, F. Koromani, M. A. Kotowicz, H. Kröger, T. Kwok, O. Lamy, D. J. Torgerson, Natasja M. van Schoor, T. P. van Staa, J. Vilà, N. J. Wareham, N. C. Wright, T. Yoshimura, M. C. Zillikens, Joost J. Zwart, N. Harvey, Mattias Lorentzon, W. D. Leslie, J A Kanis^* (Corresponding Author)

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

33 Citations (Scopus)

Abstract

We describe the collection of cohorts together with the analysis plan for an update of the fracture risk prediction tool FRAX with respect to current and novel risk factors. The resource comprises 2,138,428 participants with a follow-up of approximately 20 million person-years and 116,117 documented incident major osteoporotic fractures.

Original language	English
Pages (from-to)	2103-2136
Number of pages	34
Journal	Osteoporosis International
Volume	33
Early online date	31 May 2022
DOIs	https://doi.org/10.1007/s00198-022-06435-6
Publication status	E-pub ahead of print - 31 May 2022

Bibliographical note

Acknowledgements
We thank the Gothenburg University Library for assistance with the systematic review. We are grateful to Dr Östen Ljunggren for contributing the MrOS Sweden cohort.

Keywords

Epidemiology
Fracture probability
FRAX
Hip fracture
Major osteoporotic fracture
Risk assessment

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Vandenput, L., Johansson, H., McCloskey, E. V., Liu, E., Åkesson, K. E., Anderson, F. A., Azagra, R., Bager, C. L., Beaudart, C., Bischoff-Ferrari, H. A., Biver, E., Bruyère, O., Cauley, J. A., Center, J. R., Chapurlat, R., Christiansen, C., Cooper, C., Crandall, C. J., Cummings, S. R., ... Kanis, J. A. (2022). Update of the fracture risk prediction tool FRAX: a systematic review of potential cohorts and analysis plan. Osteoporosis International, 33, 2103-2136. Advance online publication. https://doi.org/10.1007/s00198-022-06435-6

Vandenput, L, Johansson, H, McCloskey, EV, Liu, E, Åkesson, KE, Anderson, FA, Azagra, R, Bager, CL, Beaudart, C, Bischoff-Ferrari, HA, Biver, E, Bruyère, O, Cauley, JA, Center, JR, Chapurlat, R, Christiansen, C, Cooper, C, Crandall, CJ, Cummings, SR, da Silva, JAP, Dawson-Hughes, B, Diez-Perez, A, Dufour, AB, Eisman, JA, Elders, PJM, Ferrari, S, Fujita, Y, Fujiwara, S, Glüer, C-C, Goldshtein, I, Goltzman, D, Gudnason, V, Hall, J, Hans, D, Hoff, M, Hollick, RJ, Huisman, M, Iki, M, Ish-Shalom, S, Jones, G, Karlsson, MK, Khosla, S, Kiel, DP, Koh, W-P, Koromani, F, Kotowicz, MA, Kröger, H, Kwok, T, Lamy, O, Torgerson, DJ, van Schoor, NM, van Staa, TP, Vilà, J, Wareham, NJ, Wright, NC, Yoshimura, T, Zillikens, MC, Zwart, JJ, Harvey, N, Lorentzon, M, Leslie, WD & Kanis, JA 2022, 'Update of the fracture risk prediction tool FRAX: a systematic review of potential cohorts and analysis plan', Osteoporosis International, vol. 33, pp. 2103-2136. https://doi.org/10.1007/s00198-022-06435-6

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abstract = "We describe the collection of cohorts together with the analysis plan for an update of the fracture risk prediction tool FRAX with respect to current and novel risk factors. The resource comprises 2,138,428 participants with a follow-up of approximately 20 million person-years and 116,117 documented incident major osteoporotic fractures.",

keywords = "Epidemiology, Fracture probability, FRAX, Hip fracture, Major osteoporotic fracture, Risk assessment",

author = "L. Vandenput and H. Johansson and McCloskey, {E. V.} and E. Liu and {\AA}kesson, {K. E.} and Anderson, {F. A.} and R. Azagra and Bager, {C. L.} and C. Beaudart and Bischoff-Ferrari, {H. A.} and E. Biver and O. Bruy{\`e}re and Cauley, {J. A.} and Center, {J. R.} and R. Chapurlat and C. Christiansen and C. Cooper and Crandall, {C. J.} and Cummings, {S. R.} and {da Silva}, {J. A. P.} and B. Dawson-Hughes and A. Diez-Perez and Dufour, {A. B.} and Eisman, {J. A.} and Elders, {P. J. M.} and S. Ferrari and Y. Fujita and S. Fujiwara and C.-C. Gl{\"u}er and I. Goldshtein and D. Goltzman and V. Gudnason and J. Hall and D. Hans and M. Hoff and Hollick, {R. J.} and M. Huisman and M. Iki and S. Ish-Shalom and G. Jones and Karlsson, {M. K.} and S. Khosla and Kiel, {D. P.} and W.-P. Koh and F. Koromani and Kotowicz, {M. A.} and H. Kr{\"o}ger and T. Kwok and O. Lamy and Torgerson, {D. J.} and {van Schoor}, {Natasja M.} and {van Staa}, {T. P.} and J. Vil{\`a} and Wareham, {N. J.} and Wright, {N. C.} and T. Yoshimura and Zillikens, {M. C.} and Zwart, {Joost J.} and N. Harvey and Mattias Lorentzon and Leslie, {W. D.} and Kanis, {J A}",

note = "Acknowledgements We thank the Gothenburg University Library for assistance with the systematic review. We are grateful to Dr {\"O}sten Ljunggren for contributing the MrOS Sweden cohort.",

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doi = "10.1007/s00198-022-06435-6",

language = "English",

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T1 - Update of the fracture risk prediction tool FRAX

T2 - a systematic review of potential cohorts and analysis plan

AU - Vandenput, L.

AU - Johansson, H.

AU - McCloskey, E. V.

AU - Liu, E.

AU - Åkesson, K. E.

AU - Anderson, F. A.

AU - Azagra, R.

AU - Bager, C. L.

AU - Beaudart, C.

AU - Bischoff-Ferrari, H. A.

AU - Biver, E.

AU - Bruyère, O.

AU - Cauley, J. A.

AU - Center, J. R.

AU - Chapurlat, R.

AU - Christiansen, C.

AU - Cooper, C.

AU - Crandall, C. J.

AU - Cummings, S. R.

AU - da Silva, J. A. P.

AU - Dawson-Hughes, B.

AU - Diez-Perez, A.

AU - Dufour, A. B.

AU - Eisman, J. A.

AU - Elders, P. J. M.

AU - Ferrari, S.

AU - Fujita, Y.

AU - Fujiwara, S.

AU - Glüer, C.-C.

AU - Goldshtein, I.

AU - Goltzman, D.

AU - Gudnason, V.

AU - Hall, J.

AU - Hans, D.

AU - Hoff, M.

AU - Hollick, R. J.

AU - Huisman, M.

AU - Iki, M.

AU - Ish-Shalom, S.

AU - Jones, G.

AU - Karlsson, M. K.

AU - Khosla, S.

AU - Kiel, D. P.

AU - Koh, W.-P.

AU - Koromani, F.

AU - Kotowicz, M. A.

AU - Kröger, H.

AU - Kwok, T.

AU - Lamy, O.

AU - Torgerson, D. J.

AU - van Schoor, Natasja M.

AU - van Staa, T. P.

AU - Vilà, J.

AU - Wareham, N. J.

AU - Wright, N. C.

AU - Yoshimura, T.

AU - Zillikens, M. C.

AU - Zwart, Joost J.

AU - Harvey, N.

AU - Lorentzon, Mattias

AU - Leslie, W. D.

AU - Kanis, J A

N1 - Acknowledgements We thank the Gothenburg University Library for assistance with the systematic review. We are grateful to Dr Östen Ljunggren for contributing the MrOS Sweden cohort.

PY - 2022/5/31

Y1 - 2022/5/31

N2 - We describe the collection of cohorts together with the analysis plan for an update of the fracture risk prediction tool FRAX with respect to current and novel risk factors. The resource comprises 2,138,428 participants with a follow-up of approximately 20 million person-years and 116,117 documented incident major osteoporotic fractures.

AB - We describe the collection of cohorts together with the analysis plan for an update of the fracture risk prediction tool FRAX with respect to current and novel risk factors. The resource comprises 2,138,428 participants with a follow-up of approximately 20 million person-years and 116,117 documented incident major osteoporotic fractures.

KW - Epidemiology

KW - Fracture probability

KW - FRAX

KW - Hip fracture

KW - Major osteoporotic fracture

KW - Risk assessment

U2 - 10.1007/s00198-022-06435-6

DO - 10.1007/s00198-022-06435-6

M3 - Article

SN - 1433-2965

VL - 33

SP - 2103

EP - 2136

JO - Osteoporosis International

JF - Osteoporosis International

ER -

Update of the fracture risk prediction tool FRAX: a systematic review of potential cohorts and analysis plan

Abstract

Bibliographical note

Keywords

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