Urinary soluble IL-6 receptor levels after cardiopulmonary bypass

A G Sutherland, D J Deehan

Research output: Contribution to journalArticle

5 Citations (Scopus)


To investigate the possible role of soluble interleukin 6 receptor (sIL-6r) in the inflammatory response to cardiopulmonary bypass (CPB) with extracorporeal circulation (ECC), we examined the levels of sIL-6r in the urine of 50 patients undergoing coronary artery bypass surgery. The presence of sIL-6r in urine was confirmed in these patients, with levels rising from 6 pg/ml preoperatively to 19.5 pg/ml at 6 h and 41 pg/ml at 24 h after the start of cardiopulmonary bypass. Cardiopulmonary bypass leads to a rise in sIL-6r in urine that has not returned to normal after 24 h, suggesting a role for sIL-6r acid IL-6 in the inflammatory response to such surgery. Determination of cytokine receptor presence in urine offers a non-invasive approach to the monitoring of the immune and inflammatory response to the stress of surgical and traumatic injury. (C) 2000 Academic Press.

Original languageEnglish
Pages (from-to)1441-1443
Number of pages3
Publication statusPublished - 2000


  • cardiopulmonary bypass
  • ECC
  • IL-6
  • soluble IL-6 receptor
  • surgical stress


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