Use of Hand-Held Optical Coherence Tomography during Retinopathy of Prematurity (ROP) Screening demonstrates an increased Outer Retina from early Postmenstrual Age in Preterm Infants with ROP

Samira Anwar; Mintu Nath; Aarti Patel; Straton Tyradellis; Irene Gottlob; Frank A Proudlock

doi:10.1097/IAE.0000000000003957

Use of Hand-Held Optical Coherence Tomography during Retinopathy of Prematurity (ROP) Screening demonstrates an increased Outer Retina from early Postmenstrual Age in Preterm Infants with ROP

Samira Anwar, Mintu Nath, Aarti Patel, Straton Tyradellis, Irene Gottlob, Frank A Proudlock

Research output: Contribution to journal › Article › peer-review

Abstract

PURPOSE: To identify structural markers of active retinopathy of prematurity (ROP) in foveal and parafoveal retinal layers using hand-held optical coherence tomography (HH-OCT).

METHODS: We acquired HH-OCT images (n=278) from a prospective mixed cross-sectional longitudinal observational study of 87 participants (23-36 weeks gestational age (GA); n=30 with ROP, n=57 without ROP) between 31 to 44 weeks postmenstrual age (PMA) excluding treated ROP and features of cystoid macular edema (CME). Six retinal layer thicknesses from the fovea to the parafovea were analysed at five locations up to 1000 µm temporally and nasally.

RESULTS: The mean outer retinal thickness (OUTRETL) during active ROP increased at the fovea and parafovea from PMA 33 to 39 weeks ( p <0.001) while the parafoveal inner nuclear layer (INL) and retinal nerve fiber layer (RNFL) reduced ( p <0.001). OUTRETL at the fovea from 33 to 39 weeks PMA was consistently thicker in infants with ROP across all levels of prematurity (GA).

CONCLUSIONS: Increased foveal and parafoveal outer retina measured using HH-OCT shows potential as a marker for ROP screening.

Original language	English
Journal	Retina
Early online date	23 Oct 2023
DOIs	https://doi.org/10.1097/IAE.0000000000003957
Publication status	E-pub ahead of print - 23 Oct 2023

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title = "Use of Hand-Held Optical Coherence Tomography during Retinopathy of Prematurity (ROP) Screening demonstrates an increased Outer Retina from early Postmenstrual Age in Preterm Infants with ROP",

abstract = "PURPOSE: To identify structural markers of active retinopathy of prematurity (ROP) in foveal and parafoveal retinal layers using hand-held optical coherence tomography (HH-OCT).METHODS: We acquired HH-OCT images (n=278) from a prospective mixed cross-sectional longitudinal observational study of 87 participants (23-36 weeks gestational age (GA); n=30 with ROP, n=57 without ROP) between 31 to 44 weeks postmenstrual age (PMA) excluding treated ROP and features of cystoid macular edema (CME). Six retinal layer thicknesses from the fovea to the parafovea were analysed at five locations up to 1000 µm temporally and nasally.RESULTS: The mean outer retinal thickness (OUTRETL) during active ROP increased at the fovea and parafovea from PMA 33 to 39 weeks ( p <0.001) while the parafoveal inner nuclear layer (INL) and retinal nerve fiber layer (RNFL) reduced ( p <0.001). OUTRETL at the fovea from 33 to 39 weeks PMA was consistently thicker in infants with ROP across all levels of prematurity (GA).CONCLUSIONS: Increased foveal and parafoveal outer retina measured using HH-OCT shows potential as a marker for ROP screening.",

author = "Samira Anwar and Mintu Nath and Aarti Patel and Straton Tyradellis and Irene Gottlob and Proudlock, {Frank A}",

note = "Copyright {\textcopyright} 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the Opthalmic Communications Society, Inc.",

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doi = "10.1097/IAE.0000000000003957",

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T1 - Use of Hand-Held Optical Coherence Tomography during Retinopathy of Prematurity (ROP) Screening demonstrates an increased Outer Retina from early Postmenstrual Age in Preterm Infants with ROP

AU - Anwar, Samira

AU - Nath, Mintu

AU - Patel, Aarti

AU - Tyradellis, Straton

AU - Gottlob, Irene

AU - Proudlock, Frank A

PY - 2023/10/23

Y1 - 2023/10/23

N2 - PURPOSE: To identify structural markers of active retinopathy of prematurity (ROP) in foveal and parafoveal retinal layers using hand-held optical coherence tomography (HH-OCT).METHODS: We acquired HH-OCT images (n=278) from a prospective mixed cross-sectional longitudinal observational study of 87 participants (23-36 weeks gestational age (GA); n=30 with ROP, n=57 without ROP) between 31 to 44 weeks postmenstrual age (PMA) excluding treated ROP and features of cystoid macular edema (CME). Six retinal layer thicknesses from the fovea to the parafovea were analysed at five locations up to 1000 µm temporally and nasally.RESULTS: The mean outer retinal thickness (OUTRETL) during active ROP increased at the fovea and parafovea from PMA 33 to 39 weeks ( p <0.001) while the parafoveal inner nuclear layer (INL) and retinal nerve fiber layer (RNFL) reduced ( p <0.001). OUTRETL at the fovea from 33 to 39 weeks PMA was consistently thicker in infants with ROP across all levels of prematurity (GA).CONCLUSIONS: Increased foveal and parafoveal outer retina measured using HH-OCT shows potential as a marker for ROP screening.

AB - PURPOSE: To identify structural markers of active retinopathy of prematurity (ROP) in foveal and parafoveal retinal layers using hand-held optical coherence tomography (HH-OCT).METHODS: We acquired HH-OCT images (n=278) from a prospective mixed cross-sectional longitudinal observational study of 87 participants (23-36 weeks gestational age (GA); n=30 with ROP, n=57 without ROP) between 31 to 44 weeks postmenstrual age (PMA) excluding treated ROP and features of cystoid macular edema (CME). Six retinal layer thicknesses from the fovea to the parafovea were analysed at five locations up to 1000 µm temporally and nasally.RESULTS: The mean outer retinal thickness (OUTRETL) during active ROP increased at the fovea and parafovea from PMA 33 to 39 weeks ( p <0.001) while the parafoveal inner nuclear layer (INL) and retinal nerve fiber layer (RNFL) reduced ( p <0.001). OUTRETL at the fovea from 33 to 39 weeks PMA was consistently thicker in infants with ROP across all levels of prematurity (GA).CONCLUSIONS: Increased foveal and parafoveal outer retina measured using HH-OCT shows potential as a marker for ROP screening.

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DO - 10.1097/IAE.0000000000003957

M3 - Article

C2 - 37824817

SN - 0275-004X

JO - Retina

JF - Retina

ER -

Use of Hand-Held Optical Coherence Tomography during Retinopathy of Prematurity (ROP) Screening demonstrates an increased Outer Retina from early Postmenstrual Age in Preterm Infants with ROP

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