Vaccination strategies and IgM responses against PKD in rainbow trout

M. N. Faber; J. W. Holland; C. J. Secombes

doi:10.1016/j.fsi.2019.04.159

Abstract

PKD is one of the most serious diseases affecting trout aquaculture in the UK. Caused by the myxozoan parasite, Tetracapsuloides bryosalmonae, PKD is elicited by the temperature-dependent development of parasite spore sacs in colonial bryozoans. Since recovered fish are known to exhibit protective immunity to re-infection, a successful treatment, based on the reduction of kidney pathology and parasite burden, could markedly reduce fish mortalities leading to improved productivity and fish welfare. Our investigations have focused on the selection of putative T. bryosalmonae virulence factors to unravel host immune evasion mechanisms exploited by the parasite, whilst shortlisting candidates for vaccine studies.

Copyright © 2019 Published by Elsevier Ltd.

Original language	English
Pages (from-to)	423
Number of pages	1
Journal	Fish & Shellfish Immunology
Volume	91
Early online date	17 Jun 2019
DOIs	https://doi.org/10.1016/j.fsi.2019.04.159
Publication status	Published - Aug 2019

Keywords

vaccination
myxozoan
parasite
antigen
igm response

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Cite this

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title = "Vaccination strategies and IgM responses against PKD in rainbow trout",

abstract = "PKD is one of the most serious diseases affecting trout aquaculture in the UK. Caused by the myxozoan parasite, Tetracapsuloides bryosalmonae, PKD is elicited by the temperature-dependent development of parasite spore sacs in colonial bryozoans. Since recovered fish are known to exhibit protective immunity to re-infection, a successful treatment, based on the reduction of kidney pathology and parasite burden, could markedly reduce fish mortalities leading to improved productivity and fish welfare. Our investigations have focused on the selection of putative T. bryosalmonae virulence factors to unravel host immune evasion mechanisms exploited by the parasite, whilst shortlisting candidates for vaccine studies.Copyright {\textcopyright} 2019 Published by Elsevier Ltd.",

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AU - Holland, J. W.

AU - Secombes, C. J.

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N2 - PKD is one of the most serious diseases affecting trout aquaculture in the UK. Caused by the myxozoan parasite, Tetracapsuloides bryosalmonae, PKD is elicited by the temperature-dependent development of parasite spore sacs in colonial bryozoans. Since recovered fish are known to exhibit protective immunity to re-infection, a successful treatment, based on the reduction of kidney pathology and parasite burden, could markedly reduce fish mortalities leading to improved productivity and fish welfare. Our investigations have focused on the selection of putative T. bryosalmonae virulence factors to unravel host immune evasion mechanisms exploited by the parasite, whilst shortlisting candidates for vaccine studies.Copyright © 2019 Published by Elsevier Ltd.

AB - PKD is one of the most serious diseases affecting trout aquaculture in the UK. Caused by the myxozoan parasite, Tetracapsuloides bryosalmonae, PKD is elicited by the temperature-dependent development of parasite spore sacs in colonial bryozoans. Since recovered fish are known to exhibit protective immunity to re-infection, a successful treatment, based on the reduction of kidney pathology and parasite burden, could markedly reduce fish mortalities leading to improved productivity and fish welfare. Our investigations have focused on the selection of putative T. bryosalmonae virulence factors to unravel host immune evasion mechanisms exploited by the parasite, whilst shortlisting candidates for vaccine studies.Copyright © 2019 Published by Elsevier Ltd.

KW - vaccination

KW - myxozoan

KW - parasite

KW - antigen

KW - igm response

UR - http://www.mendeley.com/research/vaccination-strategies-igm-responses-against-pkd-rainbow-trout

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M3 - Abstract

SN - 1050-4648

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JO - Fish & Shellfish Immunology

JF - Fish & Shellfish Immunology

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