Vitamin E homologues α - and γ-tocopherol are not associated with bone turnover markers or bone mineral density in perimenopausal and postmenopausal women

T C Yang, G G Duthie, L S Aucott, H M MacDonald

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)
37 Downloads (Pure)


IntroductionVitamin E has anti-oxidant and -inflammatory properties hypothesized to benefit bone, but limited studies exist regarding its homologues. We examined circulating and dietary α- and γ-tocopherols with bone turnover markers (BTMs) and bone mineral density (BMD), and the role of inflammation in this relationship. MethodsWe performed two cross-sectional analyses from two visits (V2: 1997-1999 n=3883; V3: 2007-2011 n=2130) of the Aberdeen Prospective Osteoporosis Screening Study. Dietary and supplement intake by food frequency questionnaire were assessed at both visits. V2 BTMs (urinary free pyridinoline and deoxypyridinoline, serum N-terminal propeptide of type 1 collagen) and V3 serum α- and γ-tocopherols, inflammatory markers (interleukin-6 [IL-6], serum amyloid A [SAA], high-sensitivity C-reactive protein [hs-CRP], E-selectin), and dual x-ray absorptiometry BMD at the femoral neck and lumbar spine were collected. Food sources of tocopherol homologues and diet-serum correlations were determined. The relationships between dietary tocopherols and BTMs (V2), and dietary and serum tocopherols with BMD (V3) were examined by multivariable regression (adjusting for age, cholesterol, inflammatory markers, carotenoids, body mass index, height, physical activity level, alcohol intake, smoking status, and national deprivation category).ResultsSerum γ-tocopherol was associated with increasing concentrations of hs-CRP, SAA, and E-selectin (P-trend all <0.0001), while α-tocopherol was associated with decreasing concentrations of IL-6 and hs-CRP (P-trend all <0.001). Controlling for covariates, serum α-tocopherol was positively associated with BMD at the femoral neck (β=0.002, P=0.04) among those not reporting vitamin E supplementation. ConclusionWe did not find biologically meaningful results between dietary and tocopherol homologues with BTMs or BMD.
Original languageEnglish
Pages (from-to)2281-2290
Number of pages10
JournalOsteoporosis International
Issue number7
Early online date2 May 2016
Publication statusPublished - Jul 2016

Bibliographical note

This study was supported by the Foods Standards Agency and the UK Department of Health (grant number N05086) and the Scottish Funding Council. We are grateful for funding from the Scottish Government's Rural and Environmental Science and Analytical Services (RESAS) Food, Land and People Programme. Any views expressed are the authors’ own; none of the funders had a role in design, analysis, or writing of the present study.


  • bone mineral density
  • bone markers
  • vitamin E
  • alpha-tocopherol
  • gamma-tocopherol
  • inflammation
  • postmenopausal women


Dive into the research topics of 'Vitamin E homologues α - and γ-tocopherol are not associated with bone turnover markers or bone mineral density in perimenopausal and postmenopausal women'. Together they form a unique fingerprint.

Cite this