Abstract
The isolation and Structure determination of an unusual cyclic heptapeptide. wainunuamide, from a Fijian marine sponge, Stylotella aurantium, is reported. The peptide contains three proline residues and a histidine residue, which is rare in cyclic peptides and has only Previously been reported in a cyclic peptide isolated from the cyanobacterium Oscillatoria agardhii, suggesting a possible source of the peptide. Wainunuamide is found to have weak cytotoxic activity. (C) 2001 Elsevier Science Ltd. All rights reserved.
Original language | English |
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Pages (from-to) | 9273-9276 |
Number of pages | 3 |
Journal | Tetrahedron Letters |
Volume | 42 |
DOIs | |
Publication status | Published - 2001 |
Keywords
- sponges
- cyclic peptides
- NMR
- MS
- cytotoxicity
- ANTINEOPLASTIC AGENTS
- HYMENIACIDON-SP
- CARTERI
- AXINASTATIN-4
- CYCLOPEPTIDES
- RESIDUES