Y chromosome mosaicism is associated with age-related macular degeneration

on behalf of the International Age-related Macular Degeneration Genomics Consortium (IAMDGC)

doi:10.1038/s41431-018-0238-8

Y chromosome mosaicism is associated with age-related macular degeneration

on behalf of the International Age-related Macular Degeneration Genomics Consortium (IAMDGC)

Medical Sciences

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Abstract

Age-related macular degeneration (AMD) is the leading cause of blindness in industrialised countries, and thereby a major individual but also a socio-economic burden. Y chromosome loss in nucleated blood cells has been implicated in age-related diseases such as Alzheimer disease and was shown to be caused by increasing age, smoking and genetic factors. Mosaic loss of Y chromosome (mLOY) in peripheral blood was estimated from normalised dosages of genotyping chip data covering the male-specific region of the Y chromosome. After quality control, we assessed the association of mLOY on AMD risk in 5772 male cases and 6732 male controls. In controls the prevalence of mLOY increased significantly with age, which is consistent with previous reports. Importantly, mLOY was associated with late-stage AMD with genome-wide significance (OR: 1.332 [95% CI: 1.206; 1.472], P = 1.60e-08), independent of age, the AMD genetic risk score and the first two principle components of ancestry. Additionally conditioning on smoking behaviour had no influence on the observed association strength. mLOY was strongest associated in individuals aged between 65 and 75 years. Taken together, mLOY is significantly associated with risk for AMD, independent of known and potential confounding factors.

Original language	English
Pages (from-to)	36-41
Number of pages	6
Journal	European Journal of Human Genetics
Volume	27
Early online date	29 Aug 2018
DOIs	https://doi.org/10.1038/s41431-018-0238-8
Publication status	Published - Jan 2019

Bibliographical note

Acknowledgements
The authors thank Sudha K. Iyengar, Rob Igo and Alberto H. Santana (Case Western Reserve University, Cleveland, Ohio, USA) as well as the IAMDGC (http://eaglep.case.edu/iamdgc_web/) for providing the raw probe intensities. We are also grateful to valuable comments to the manuscript from Michael Gorin (Jules Stein Eye Institute, Los Angeles, CA, USA). The list of consortium members reflects the author list of the previous publication by Fritsche et al. 2016 [9], which is listed in the Supplement.

Funding
The work was funded, in parts by a grant from the German Research Foundation (GR 5065/1-1 to FG) and institutional funds of the Institute of Human Genetics, University of Regensburg (TG77 to BHFW). Genotyping was conducted as part of the IAMDGC exome-chip project supported by CIDR (contract number HHSN268201200008I) and funded by EY022310 (to Jonathan L. Haines, Case Western Reserve University, Cleveland) and 1 × 01HG006934-01 (to Gonçalo R. Abecasis, University of Michigan, Department of Biostatistics). The funding bodies had no role in the design of the study and collection, analysis, and interpretation of data and in writing the manuscript.

Keywords

Genome-wide association studies
predictive markers

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Cite this

@article{2acb2d4861c4479cadbda2f08ba4dfed,

title = "Y chromosome mosaicism is associated with age-related macular degeneration",

abstract = "Age-related macular degeneration (AMD) is the leading cause of blindness in industrialised countries, and thereby a major individual but also a socio-economic burden. Y chromosome loss in nucleated blood cells has been implicated in age-related diseases such as Alzheimer disease and was shown to be caused by increasing age, smoking and genetic factors. Mosaic loss of Y chromosome (mLOY) in peripheral blood was estimated from normalised dosages of genotyping chip data covering the male-specific region of the Y chromosome. After quality control, we assessed the association of mLOY on AMD risk in 5772 male cases and 6732 male controls. In controls the prevalence of mLOY increased significantly with age, which is consistent with previous reports. Importantly, mLOY was associated with late-stage AMD with genome-wide significance (OR: 1.332 [95% CI: 1.206; 1.472], P = 1.60e-08), independent of age, the AMD genetic risk score and the first two principle components of ancestry. Additionally conditioning on smoking behaviour had no influence on the observed association strength. mLOY was strongest associated in individuals aged between 65 and 75 years. Taken together, mLOY is significantly associated with risk for AMD, independent of known and potential confounding factors.",

keywords = "Genome-wide association studies, predictive markers",

author = "Felix Grassmann and Christina Kiel and {den Hollander}, {Anneke I.} and Weeks, {Daniel E.} and Andrew Lotery and Valentina Cipriani and Weber, {Bernhard H.F.} and {on behalf of the International Age-related Macular Degeneration Genomics Consortium (IAMDGC)}",

note = "Acknowledgements The authors thank Sudha K. Iyengar, Rob Igo and Alberto H. Santana (Case Western Reserve University, Cleveland, Ohio, USA) as well as the IAMDGC (http://eaglep.case.edu/iamdgc_web/) for providing the raw probe intensities. We are also grateful to valuable comments to the manuscript from Michael Gorin (Jules Stein Eye Institute, Los Angeles, CA, USA). The list of consortium members reflects the author list of the previous publication by Fritsche et al. 2016 [9], which is listed in the Supplement. Funding The work was funded, in parts by a grant from the German Research Foundation (GR 5065/1-1 to FG) and institutional funds of the Institute of Human Genetics, University of Regensburg (TG77 to BHFW). Genotyping was conducted as part of the IAMDGC exome-chip project supported by CIDR (contract number HHSN268201200008I) and funded by EY022310 (to Jonathan L. Haines, Case Western Reserve University, Cleveland) and 1 × 01HG006934-01 (to Gon{\c c}alo R. Abecasis, University of Michigan, Department of Biostatistics). The funding bodies had no role in the design of the study and collection, analysis, and interpretation of data and in writing the manuscript.",

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doi = "10.1038/s41431-018-0238-8",

language = "English",

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journal = "European Journal of Human Genetics",

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T1 - Y chromosome mosaicism is associated with age-related macular degeneration

AU - Grassmann, Felix

AU - Kiel, Christina

AU - den Hollander, Anneke I.

AU - Weeks, Daniel E.

AU - Lotery, Andrew

AU - Cipriani, Valentina

AU - Weber, Bernhard H.F.

AU - on behalf of the International Age-related Macular Degeneration Genomics Consortium (IAMDGC)

N1 - Acknowledgements The authors thank Sudha K. Iyengar, Rob Igo and Alberto H. Santana (Case Western Reserve University, Cleveland, Ohio, USA) as well as the IAMDGC (http://eaglep.case.edu/iamdgc_web/) for providing the raw probe intensities. We are also grateful to valuable comments to the manuscript from Michael Gorin (Jules Stein Eye Institute, Los Angeles, CA, USA). The list of consortium members reflects the author list of the previous publication by Fritsche et al. 2016 [9], which is listed in the Supplement. Funding The work was funded, in parts by a grant from the German Research Foundation (GR 5065/1-1 to FG) and institutional funds of the Institute of Human Genetics, University of Regensburg (TG77 to BHFW). Genotyping was conducted as part of the IAMDGC exome-chip project supported by CIDR (contract number HHSN268201200008I) and funded by EY022310 (to Jonathan L. Haines, Case Western Reserve University, Cleveland) and 1 × 01HG006934-01 (to Gonçalo R. Abecasis, University of Michigan, Department of Biostatistics). The funding bodies had no role in the design of the study and collection, analysis, and interpretation of data and in writing the manuscript.

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N2 - Age-related macular degeneration (AMD) is the leading cause of blindness in industrialised countries, and thereby a major individual but also a socio-economic burden. Y chromosome loss in nucleated blood cells has been implicated in age-related diseases such as Alzheimer disease and was shown to be caused by increasing age, smoking and genetic factors. Mosaic loss of Y chromosome (mLOY) in peripheral blood was estimated from normalised dosages of genotyping chip data covering the male-specific region of the Y chromosome. After quality control, we assessed the association of mLOY on AMD risk in 5772 male cases and 6732 male controls. In controls the prevalence of mLOY increased significantly with age, which is consistent with previous reports. Importantly, mLOY was associated with late-stage AMD with genome-wide significance (OR: 1.332 [95% CI: 1.206; 1.472], P = 1.60e-08), independent of age, the AMD genetic risk score and the first two principle components of ancestry. Additionally conditioning on smoking behaviour had no influence on the observed association strength. mLOY was strongest associated in individuals aged between 65 and 75 years. Taken together, mLOY is significantly associated with risk for AMD, independent of known and potential confounding factors.

AB - Age-related macular degeneration (AMD) is the leading cause of blindness in industrialised countries, and thereby a major individual but also a socio-economic burden. Y chromosome loss in nucleated blood cells has been implicated in age-related diseases such as Alzheimer disease and was shown to be caused by increasing age, smoking and genetic factors. Mosaic loss of Y chromosome (mLOY) in peripheral blood was estimated from normalised dosages of genotyping chip data covering the male-specific region of the Y chromosome. After quality control, we assessed the association of mLOY on AMD risk in 5772 male cases and 6732 male controls. In controls the prevalence of mLOY increased significantly with age, which is consistent with previous reports. Importantly, mLOY was associated with late-stage AMD with genome-wide significance (OR: 1.332 [95% CI: 1.206; 1.472], P = 1.60e-08), independent of age, the AMD genetic risk score and the first two principle components of ancestry. Additionally conditioning on smoking behaviour had no influence on the observed association strength. mLOY was strongest associated in individuals aged between 65 and 75 years. Taken together, mLOY is significantly associated with risk for AMD, independent of known and potential confounding factors.

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ER -

Y chromosome mosaicism is associated with age-related macular degeneration

Abstract

Bibliographical note

Keywords

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