During screening of human gut isolates in search of novel antimicrobials, the butyrate-producing strain Roseburia faecis M72/1 was found to produce an inhibitory substance active against Bacillus subtilis. Partial purification of the antimicrobial was achieved and activity found to be heat labile. Our findings suggest that R. faecis M72/1 produces a proteinaceous inhibitor whose production may be triggered by trypsin in the gastrointestinal tract. (c) 2013 Elsevier Ltd. All rights reserved.
Bibliographical noteThis work was supported by a Biotechnology and Biological Sciences Research Council studentship grant to DH. SHD and HJF acknowledge support from the Scottish Government RESAS programme.
- roseburia faecis
- bacteriocin-like inhibitory substance (BLIS)
- firmicutes anaerobe
- gut microbiota
- ruminococcus-gnavus strain
- lactic-acid bacteria
- human feces