Directing the H2-driven Selective Regeneration of NADH via Sn-doped Pt/SiO2

Joseph William H. Burnett, Jianwei Li, Alan J McCue, Panagiotis Kechagiopoulos, R. F. Howe, Xiaodong Wang* (Corresponding Author)

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)
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H2-driven NADH regeneration has long suffered from low selectivity when non-enzymatic, particularly heterogeneous catalysts, are used. In addition to the unselective nature of the catalysts, the typically unmeasured NAD+ conversion has inevitably hindered catalyst development. Here we report Sn-doped Pt/SiO2 catalysts for the selective regeneration of NADH and show that doping Pt/SiO2 with 10 at.% Sn can deliver a selectivity of 90% (at ~100% conversion) using H2. We propose that this is a result of Sn disturbing the Pt ensemble, altering the mode of NAD+ adsorption and directing the reduction to the 1,4- position of the nicotinamide ring.
Original languageEnglish
Pages (from-to)1451-1455
JournalGreen Chemistry
Issue number4
Early online date31 Jan 2022
Publication statusPublished - 2022

Bibliographical note

This work was supported by the EPSRC New Horizons scheme (EP/V048635/1) and The Royal Society (ICA\R1\180317). We are also grateful for support from the UK Catalysis Hub funded by EPSRC grant reference EP/R026645/1.


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