Directing the H2-driven Selective Regeneration of NADH via Sn-doped Pt/SiO2

Joseph William H. Burnett; Jianwei Li; Alan J McCue; Panagiotis Kechagiopoulos; R. F. Howe; Xiaodong Wang

doi:10.1039/D1GC04414A

Directing the H2-driven Selective Regeneration of NADH via Sn-doped Pt/SiO2

Joseph William H. Burnett, Jianwei Li, Alan J McCue, Panagiotis Kechagiopoulos, R. F. Howe, Xiaodong Wang^* (Corresponding Author)

^*Corresponding author for this work

Lancaster University

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

5 Downloads (Pure)

Abstract

H2-driven NADH regeneration has long suffered from low selectivity when non-enzymatic, particularly heterogeneous catalysts, are used. In addition to the unselective nature of the catalysts, the typically unmeasured NAD+ conversion has inevitably hindered catalyst development. Here we report Sn-doped Pt/SiO2 catalysts for the selective regeneration of NADH and show that doping Pt/SiO2 with 10 at.% Sn can deliver a selectivity of 90% (at ~100% conversion) using H2. We propose that this is a result of Sn disturbing the Pt ensemble, altering the mode of NAD+ adsorption and directing the reduction to the 1,4- position of the nicotinamide ring.

Original language	English
Pages (from-to)	1451-1455
Journal	Green Chemistry
Volume	24
Issue number	4
Early online date	31 Jan 2022
DOIs	https://doi.org/10.1039/D1GC04414A
Publication status	Published - 2022

Bibliographical note

This work was supported by the EPSRC New Horizons scheme (EP/V048635/1) and The Royal Society (ICA\R1\180317). We are also grateful for support from the UK Catalysis Hub funded by EPSRC grant reference EP/R026645/1.

Access to Document

10.1039/D1GC04414ALicence: CC BY-NC

Burnett_etal_GC_Directing_The_H2-Driven_AAMAccepted author manuscript, 2.58 MBLicence: Unspecified
Burnett_etal_GC_Directing_The_H2-drive_Vor
This article is Open Access under the Creative Commons BY-NC license
Final published version, 2.21 MBLicence: CC BY-NC

Cite this

@article{b30516962d3b4c6bb2a633ecfd408d4c,

title = "Directing the H2-driven Selective Regeneration of NADH via Sn-doped Pt/SiO2",

abstract = "H2-driven NADH regeneration has long suffered from low selectivity when non-enzymatic, particularly heterogeneous catalysts, are used. In addition to the unselective nature of the catalysts, the typically unmeasured NAD+ conversion has inevitably hindered catalyst development. Here we report Sn-doped Pt/SiO2 catalysts for the selective regeneration of NADH and show that doping Pt/SiO2 with 10 at.% Sn can deliver a selectivity of 90% (at ~100% conversion) using H2. We propose that this is a result of Sn disturbing the Pt ensemble, altering the mode of NAD+ adsorption and directing the reduction to the 1,4- position of the nicotinamide ring.",

author = "Burnett, {Joseph William H.} and Jianwei Li and McCue, {Alan J} and Panagiotis Kechagiopoulos and Howe, {R. F.} and Xiaodong Wang",

note = "This work was supported by the EPSRC New Horizons scheme (EP/V048635/1) and The Royal Society (ICA\R1\180317). We are also grateful for support from the UK Catalysis Hub funded by EPSRC grant reference EP/R026645/1.",

year = "2022",

doi = "10.1039/D1GC04414A",

language = "English",

volume = "24",

pages = "1451--1455",

journal = "Green Chemistry",

number = "4",

}

TY - JOUR

T1 - Directing the H2-driven Selective Regeneration of NADH via Sn-doped Pt/SiO2

AU - Burnett, Joseph William H.

AU - Li, Jianwei

AU - McCue, Alan J

AU - Kechagiopoulos, Panagiotis

AU - Howe, R. F.

AU - Wang, Xiaodong

N1 - This work was supported by the EPSRC New Horizons scheme (EP/V048635/1) and The Royal Society (ICA\R1\180317). We are also grateful for support from the UK Catalysis Hub funded by EPSRC grant reference EP/R026645/1.

PY - 2022

Y1 - 2022

N2 - H2-driven NADH regeneration has long suffered from low selectivity when non-enzymatic, particularly heterogeneous catalysts, are used. In addition to the unselective nature of the catalysts, the typically unmeasured NAD+ conversion has inevitably hindered catalyst development. Here we report Sn-doped Pt/SiO2 catalysts for the selective regeneration of NADH and show that doping Pt/SiO2 with 10 at.% Sn can deliver a selectivity of 90% (at ~100% conversion) using H2. We propose that this is a result of Sn disturbing the Pt ensemble, altering the mode of NAD+ adsorption and directing the reduction to the 1,4- position of the nicotinamide ring.

AB - H2-driven NADH regeneration has long suffered from low selectivity when non-enzymatic, particularly heterogeneous catalysts, are used. In addition to the unselective nature of the catalysts, the typically unmeasured NAD+ conversion has inevitably hindered catalyst development. Here we report Sn-doped Pt/SiO2 catalysts for the selective regeneration of NADH and show that doping Pt/SiO2 with 10 at.% Sn can deliver a selectivity of 90% (at ~100% conversion) using H2. We propose that this is a result of Sn disturbing the Pt ensemble, altering the mode of NAD+ adsorption and directing the reduction to the 1,4- position of the nicotinamide ring.

U2 - 10.1039/D1GC04414A

DO - 10.1039/D1GC04414A

M3 - Article

VL - 24

SP - 1451

EP - 1455

JO - Green Chemistry

JF - Green Chemistry

IS - 4

ER -

Directing the H2-driven Selective Regeneration of NADH via Sn-doped Pt/SiO2

Abstract

Bibliographical note

Access to Document

Fingerprint

Cite this