#ESHREjc report: failed fertilization: is genetic incompatibility the elephant in the room?

Sofia Makieva; Juan J. Fraire-Zamora; Mina Mincheva; Julia Uraji; Zoya E. Ali; Omar F. Ammar; George Liperis; Munevver Serdarogullari; Enrica Bianchi; Jonathan Pettitt; Karen Sermon; Siladitya Bhattacharya; Claudia Massarotti

doi:10.1093/humrep/deac265

#ESHREjc report: failed fertilization: is genetic incompatibility the elephant in the room?

Sofia Makieva, Juan J. Fraire-Zamora, Mina Mincheva, Julia Uraji, Zoya E. Ali, Omar F. Ammar, George Liperis, Munevver Serdarogullari, Enrica Bianchi, Jonathan Pettitt, Karen Sermon, Siladitya Bhattacharya, Claudia Massarotti^* (Corresponding Author)

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Peer Perspectives

A recently published opinion paper by Dr Jukka Kekäläinen hypothesized that cryptic female choice (CFC), i.e. female-driven mechanisms that act primarily prior to or during fertilization and bias it towards the sperm of specific males, could also be involved in human fertilization (Kekäläinen, 2021). As the human species is labelled inefficient with regards to reproduction and the success rate of ART has not increased in the last decades (Gleicher et al., 2019), the idea that gamete compatibility could be the missing puzzle piece to complete our understanding of the intricate process of fertilization and partly explain the phenomenon of fertilization failure, is fascinating...

Original language	English
Pages (from-to)	324-327
Number of pages	4
Journal	Human reproduction (Oxford, England)
Volume	38
Issue number	2
Early online date	30 Dec 2022
DOIs	https://doi.org/10.1093/humrep/deac265
Publication status	Published - 1 Feb 2023
Event	ESHRE Journal Club Annual Meeting - Milan, Italy Duration: 6 Jul 2022 → 6 Jul 2022

Bibliographical note

Acknowledgements
The authors thank the author of the discussed paper, Dr Jukka Kekalainen; the Editor-in-Chief of Human Reproduction, Prof. Nils Lambalk; and all the participants (both in person and virtual) of the ESHRE live journal club at the ESHRE 2022 Annual Meeting.

Funding
This research did not receive any specific grant from funding agencies in the public, commercial or not-for-profit sectors.

Data Availability Statement

No datasets were generated or analysed in this article.

Access to Document

10.1093/humrep/deac265Licence: Unspecified

Cite this

Makieva, S., Fraire-Zamora, J. J., Mincheva, M., Uraji, J., Ali, Z. E., Ammar, O. F., Liperis, G., Serdarogullari, M., Bianchi, E., Pettitt, J., Sermon, K., Bhattacharya, S., & Massarotti, C. (2023). #ESHREjc report: failed fertilization: is genetic incompatibility the elephant in the room? Human reproduction (Oxford, England), 38(2), 324-327. https://doi.org/10.1093/humrep/deac265

Makieva, S, Fraire-Zamora, JJ, Mincheva, M, Uraji, J, Ali, ZE, Ammar, OF, Liperis, G, Serdarogullari, M, Bianchi, E, Pettitt, J, Sermon, K, Bhattacharya, S & Massarotti, C 2023, '#ESHREjc report: failed fertilization: is genetic incompatibility the elephant in the room?', Human reproduction (Oxford, England), vol. 38, no. 2, pp. 324-327. https://doi.org/10.1093/humrep/deac265

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title = "#ESHREjc report: failed fertilization: is genetic incompatibility the elephant in the room?",

abstract = "Peer PerspectivesA recently published opinion paper by Dr Jukka Kek{\"a}l{\"a}inen hypothesized that cryptic female choice (CFC), i.e. female-driven mechanisms that act primarily prior to or during fertilization and bias it towards the sperm of specific males, could also be involved in human fertilization (Kek{\"a}l{\"a}inen, 2021). As the human species is labelled inefficient with regards to reproduction and the success rate of ART has not increased in the last decades (Gleicher et al., 2019), the idea that gamete compatibility could be the missing puzzle piece to complete our understanding of the intricate process of fertilization and partly explain the phenomenon of fertilization failure, is fascinating...",

author = "Sofia Makieva and Fraire-Zamora, {Juan J.} and Mina Mincheva and Julia Uraji and Ali, {Zoya E.} and Ammar, {Omar F.} and George Liperis and Munevver Serdarogullari and Enrica Bianchi and Jonathan Pettitt and Karen Sermon and Siladitya Bhattacharya and Claudia Massarotti",

note = "Acknowledgements The authors thank the author of the discussed paper, Dr Jukka Kekalainen; the Editor-in-Chief of Human Reproduction, Prof. Nils Lambalk; and all the participants (both in person and virtual) of the ESHRE live journal club at the ESHRE 2022 Annual Meeting. Funding This research did not receive any specific grant from funding agencies in the public, commercial or not-for-profit sectors.; ESHRE Journal Club Annual Meeting ; Conference date: 06-07-2022 Through 06-07-2022",

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AU - Ammar, Omar F.

AU - Liperis, George

AU - Serdarogullari, Munevver

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AU - Pettitt, Jonathan

AU - Sermon, Karen

AU - Bhattacharya, Siladitya

AU - Massarotti, Claudia

N1 - Acknowledgements The authors thank the author of the discussed paper, Dr Jukka Kekalainen; the Editor-in-Chief of Human Reproduction, Prof. Nils Lambalk; and all the participants (both in person and virtual) of the ESHRE live journal club at the ESHRE 2022 Annual Meeting. Funding This research did not receive any specific grant from funding agencies in the public, commercial or not-for-profit sectors.

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AB - Peer PerspectivesA recently published opinion paper by Dr Jukka Kekäläinen hypothesized that cryptic female choice (CFC), i.e. female-driven mechanisms that act primarily prior to or during fertilization and bias it towards the sperm of specific males, could also be involved in human fertilization (Kekäläinen, 2021). As the human species is labelled inefficient with regards to reproduction and the success rate of ART has not increased in the last decades (Gleicher et al., 2019), the idea that gamete compatibility could be the missing puzzle piece to complete our understanding of the intricate process of fertilization and partly explain the phenomenon of fertilization failure, is fascinating...

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#ESHREjc report: failed fertilization: is genetic incompatibility the elephant in the room?

Abstract

Bibliographical note

Data Availability Statement

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