Mechanism of Water Dynamics in Hyaluronic Dermal Fillers Revealed by Nuclear Magnetic Resonance Relaxometry

Danuta Kruk; Pawel Rochowski; Elzbieta Masiewicz; Slawomir Wilczynski; Milosz Wojciechowski; Lionel Broche; David Lurie

doi:10.1002/cphc.201900761

Mechanism of Water Dynamics in Hyaluronic Dermal Fillers Revealed by Nuclear Magnetic Resonance Relaxometry

Danuta Kruk^* (Corresponding Author), Pawel Rochowski, Elzbieta Masiewicz, Slawomir Wilczynski, Milosz Wojciechowski, Lionel Broche, David Lurie

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

4 Downloads (Pure)

Abstract

1H spin-lattice Nuclear Magnetic Resonance relaxation experiment were performed for five kinds of dermal fillers based on hyaluronic acid. The relaxation data were collected over a broad frequency range from 4kHz to 40MHz, at body temperature. Thanks to the frequency range encompassing four orders of magnitude, the scenarios of dynamics of water confined in the polymeric matrices were revealed. It was demonstrated that translation diffusion of the confined water molecules exhibits a two-dimensional (2D) character and the diffusion process is slower than diffusion in bulk water by 3-4 orders-of-magnitude. As far as rotational dynamics of the confined water is concerned, it was shown that in all cases there is a water pool characterized by a rotational correlation time of about 4*10-9s. In some of the dermal fillers a fraction of the confined water (about 10%) forms a pool that exhibits considerably slower (by an order-of-magnitude) rotational dynamics. In addition, the water binding capacity of the dermal fillers was quantitatively compared.

Original language	English
Pages (from-to)	2816-2822
Number of pages	7
Journal	ChemPhysChem
Volume	20
Issue number	21
Early online date	17 Oct 2019
DOIs	https://doi.org/10.1002/cphc.201900761
Publication status	Published - 5 Nov 2019

Bibliographical note

This project has received funding from the European Union’s Horizon 2020 research and innovation programme under project “IDentIFY”, grant agreement No 668119.

Keywords

diffusion
relaxation
Nuclear Magnetic Resonance
molecular dynamics
gels
spin relaxation
acid
translational diffusion
nuclear magnetic resonance
bulk
field-cycling NMR
liquids
ACID
TRANSLATIONAL DIFFUSION
BULK
FIELD-CYCLING NMR
SPIN RELAXATION
LIQUIDS

Access to Document

10.1002/cphc.201900761Licence: CC BY

Kruk_etal_cphc_Mechanism_of_Water_VOR
©2019 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. https://creativecommons.org/licenses/by/4.0/
Final published version, 799 KBLicence: CC BY

Cite this

@article{4d46c21c1a384d5096fcce14605d464f,

title = "Mechanism of Water Dynamics in Hyaluronic Dermal Fillers Revealed by Nuclear Magnetic Resonance Relaxometry",

abstract = "1H spin-lattice Nuclear Magnetic Resonance relaxation experiment were performed for five kinds of dermal fillers based on hyaluronic acid. The relaxation data were collected over a broad frequency range from 4kHz to 40MHz, at body temperature. Thanks to the frequency range encompassing four orders of magnitude, the scenarios of dynamics of water confined in the polymeric matrices were revealed. It was demonstrated that translation diffusion of the confined water molecules exhibits a two-dimensional (2D) character and the diffusion process is slower than diffusion in bulk water by 3-4 orders-of-magnitude. As far as rotational dynamics of the confined water is concerned, it was shown that in all cases there is a water pool characterized by a rotational correlation time of about 4*10-9s. In some of the dermal fillers a fraction of the confined water (about 10%) forms a pool that exhibits considerably slower (by an order-of-magnitude) rotational dynamics. In addition, the water binding capacity of the dermal fillers was quantitatively compared.",

keywords = "diffusion, relaxation, Nuclear Magnetic Resonance, molecular dynamics, gels, spin relaxation, acid, translational diffusion, nuclear magnetic resonance, bulk, field-cycling NMR, liquids, ACID, TRANSLATIONAL DIFFUSION, BULK, FIELD-CYCLING NMR, SPIN RELAXATION, LIQUIDS",

author = "Danuta Kruk and Pawel Rochowski and Elzbieta Masiewicz and Slawomir Wilczynski and Milosz Wojciechowski and Lionel Broche and David Lurie",

note = "This project has received funding from the European Union{\textquoteright}s Horizon 2020 research and innovation programme under project “IDentIFY”, grant agreement No 668119.",

year = "2019",

month = nov,

day = "5",

doi = "10.1002/cphc.201900761",

language = "English",

volume = "20",

pages = "2816--2822",

journal = "ChemPhysChem",

issn = "1439-4235",

publisher = "WILEY-V C H VERLAG GMBH",

number = "21",

}

TY - JOUR

T1 - Mechanism of Water Dynamics in Hyaluronic Dermal Fillers Revealed by Nuclear Magnetic Resonance Relaxometry

AU - Kruk, Danuta

AU - Rochowski, Pawel

AU - Masiewicz, Elzbieta

AU - Wilczynski, Slawomir

AU - Wojciechowski, Milosz

AU - Broche, Lionel

AU - Lurie, David

N1 - This project has received funding from the European Union’s Horizon 2020 research and innovation programme under project “IDentIFY”, grant agreement No 668119.

PY - 2019/11/5

Y1 - 2019/11/5

N2 - 1H spin-lattice Nuclear Magnetic Resonance relaxation experiment were performed for five kinds of dermal fillers based on hyaluronic acid. The relaxation data were collected over a broad frequency range from 4kHz to 40MHz, at body temperature. Thanks to the frequency range encompassing four orders of magnitude, the scenarios of dynamics of water confined in the polymeric matrices were revealed. It was demonstrated that translation diffusion of the confined water molecules exhibits a two-dimensional (2D) character and the diffusion process is slower than diffusion in bulk water by 3-4 orders-of-magnitude. As far as rotational dynamics of the confined water is concerned, it was shown that in all cases there is a water pool characterized by a rotational correlation time of about 4*10-9s. In some of the dermal fillers a fraction of the confined water (about 10%) forms a pool that exhibits considerably slower (by an order-of-magnitude) rotational dynamics. In addition, the water binding capacity of the dermal fillers was quantitatively compared.

AB - 1H spin-lattice Nuclear Magnetic Resonance relaxation experiment were performed for five kinds of dermal fillers based on hyaluronic acid. The relaxation data were collected over a broad frequency range from 4kHz to 40MHz, at body temperature. Thanks to the frequency range encompassing four orders of magnitude, the scenarios of dynamics of water confined in the polymeric matrices were revealed. It was demonstrated that translation diffusion of the confined water molecules exhibits a two-dimensional (2D) character and the diffusion process is slower than diffusion in bulk water by 3-4 orders-of-magnitude. As far as rotational dynamics of the confined water is concerned, it was shown that in all cases there is a water pool characterized by a rotational correlation time of about 4*10-9s. In some of the dermal fillers a fraction of the confined water (about 10%) forms a pool that exhibits considerably slower (by an order-of-magnitude) rotational dynamics. In addition, the water binding capacity of the dermal fillers was quantitatively compared.

KW - diffusion

KW - relaxation

KW - Nuclear Magnetic Resonance

KW - molecular dynamics

KW - gels

KW - spin relaxation

KW - acid

KW - translational diffusion

KW - nuclear magnetic resonance

KW - bulk

KW - field-cycling NMR

KW - liquids

KW - ACID

KW - TRANSLATIONAL DIFFUSION

KW - BULK

KW - FIELD-CYCLING NMR

KW - SPIN RELAXATION

KW - LIQUIDS

UR - https://onlinelibrary.wiley.com/doi/abs/10.1002/cphc.201900761

UR - http://www.mendeley.com/research/mechanism-water-dynamics-hyaluronic-dermal-fillers-revealed-nuclear-magnetic-resonance-relaxometry

UR - http://www.scopus.com/inward/record.url?scp=85074439848&partnerID=8YFLogxK

U2 - 10.1002/cphc.201900761

DO - 10.1002/cphc.201900761

M3 - Article

C2 - 31532873

SN - 1439-4235

VL - 20

SP - 2816

EP - 2822

JO - ChemPhysChem

JF - ChemPhysChem

IS - 21

ER -

Mechanism of Water Dynamics in Hyaluronic Dermal Fillers Revealed by Nuclear Magnetic Resonance Relaxometry

Abstract

Bibliographical note

Keywords

Access to Document

Other files and links

Fingerprint

Lionel Broche, M

Cite this

Mechanism of Water Dynamics in Hyaluronic Dermal Fillers Revealed by Nuclear Magnetic Resonance Relaxometry

Abstract

Bibliographical note

Keywords

Access to Document

Other files and links

Fingerprint

Profiles

Lionel Broche, M

Cite this