Mechanism of Water Dynamics in Hyaluronic Dermal Fillers Revealed by Nuclear Magnetic Resonance Relaxometry

Danuta Kruk* (Corresponding Author), Pawel Rochowski, Elzbieta Masiewicz, Slawomir Wilczynski, Milosz Wojciechowski, Lionel Broche, David Lurie

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)
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1H spin-lattice Nuclear Magnetic Resonance relaxation experiment were performed for five kinds of dermal fillers based on hyaluronic acid. The relaxation data were collected over a broad frequency range from 4kHz to 40MHz, at body temperature. Thanks to the frequency range encompassing four orders of magnitude, the scenarios of dynamics of water confined in the polymeric matrices were revealed. It was demonstrated that translation diffusion of the confined water molecules exhibits a two-dimensional (2D) character and the diffusion process is slower than diffusion in bulk water by 3-4 orders-of-magnitude. As far as rotational dynamics of the confined water is concerned, it was shown that in all cases there is a water pool characterized by a rotational correlation time of about 4*10-9s. In some of the dermal fillers a fraction of the confined water (about 10%) forms a pool that exhibits considerably slower (by an order-of-magnitude) rotational dynamics. In addition, the water binding capacity of the dermal fillers was quantitatively compared.

Original languageEnglish
Pages (from-to)2816-2822
Number of pages7
Issue number21
Early online date17 Oct 2019
Publication statusPublished - 5 Nov 2019

Bibliographical note

This project has received funding from the European Union’s Horizon 2020 research and innovation programme under project “IDentIFY”, grant agreement No 668119.


  • diffusion
  • relaxation
  • Nuclear Magnetic Resonance
  • molecular dynamics
  • gels
  • spin relaxation
  • acid
  • translational diffusion
  • nuclear magnetic resonance
  • bulk
  • field-cycling NMR
  • liquids
  • ACID
  • BULK


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