Melatonin receptors and signal transduction mechanisms

Perry Barrett, M Morris, W S Choi, Alexander Ross, Peter John Morgan

Research output: Contribution to journalArticlepeer-review

37 Citations (Scopus)


The ovine pars tuberalis (PT) still offers the best model for the study of signal transduction pathways regulated by the melatonin receptor, From the evidence accumulated so far, it seems likely that the cAMP signal transduction pathway will be a major effector of a stimulatory signal to the PT which can be regulated by melatonin. Thus a principal action of melatonin in the PT may be the repression of biochemical processes driven by cAMP, However, through the phenomenon of sensitization, melatonin may also act to amplify a stimulatory input to the cAMP signal transduction pathway in the PT, These events are mediated via the melatonin receptor, which is itself a target for regulation by the melatonin signal, Studies using the PT have identified several signalling pathways that may serve to positively or negatively regulate the expression of the melatonin receptor, These and other studies in the PT have alluded to cAMP-independent pathways regulated by the melatonin receptor.

Original languageEnglish
Pages (from-to)6-14
Number of pages9
JournalBiological Signals and Receptors
Issue number1-2
Publication statusPublished - 1999


  • receptor regulation
  • sensitization
  • pars tuberalis
  • adenylate cyclase
  • ovine pars-tuberalis
  • activated protein-kinase
  • adenylate-cyclase
  • expression
  • pituitary
  • brain
  • rat
  • transcription
  • localization
  • prolactin


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