New phenothiazine diaminium compounds are tau protein aggregation inhibitors, useful to treat e.g. Alzheimer's disease, Pick's disease, progressive supranuclear palsy, frontotemporal dementia and frontotemporal lobar degeneration syndromes

Thomas Baddeley; Scott Clunas; Charles Robert Harrington; David Horsley; Ahtsham Ishaq; Karrar Khan; Yin Sze Loh; Colin Marshall; Janet Elizabeth Rickard; Michael Simpson; James Peter Sinclair; John M. D. Storey; Craig Williamson; Claude Michel Wischik; Barry Alan Wood

New phenothiazine diaminium compounds are tau protein aggregation inhibitors, useful to treat e.g. Alzheimer's disease, Pick's disease, progressive supranuclear palsy, frontotemporal dementia and frontotemporal lobar degeneration syndromes

Thomas Baddeley (Inventor), Scott Clunas (Inventor), Charles Robert Harrington (Inventor), David Horsley (Inventor), Ahtsham Ishaq (Inventor), Karrar Khan (Inventor), Yin Sze Loh (Inventor), Colin Marshall (Inventor), Janet Elizabeth Rickard (Inventor), Michael Simpson (Inventor), James Peter Sinclair (Inventor), John M. D. Storey (Inventor), Craig Williamson (Inventor), Claude Michel Wischik (Inventor), Barry Alan Wood (Inventor)

TauRx Therapeutics Ltd

Research output: Patent

Abstract

PATENT CITATIONS
WO1996030766A1 Inhibition of tau-tau-association
WO2002055720A2 Materials and methods relating to protein aggregation in neurodegenerative disease
WO2002075318A2 Neurofibrillary labels
WO2005030676A1 Methods of [11c]-radiolabelling phenothiazine and phenothiazine-like compounds
WO2007110627A2 3,7-diamino-10h-phenothiazine salts and their use
WO2007110630A1 Thioninium compounds and their use
WO2008007074A2 Methods of synthesis and/or purification of diaminophenothiazinium compounds
WO2008155533A2 Phenothiazine compounds for treating mild cognitive impairment
GB2007001105W
GB2008002066W
US4880373 Tablet press

Wista Laboratories Ltd.

Original language	English
Patent number	WO2012107706-A1
Priority date	11/02/11
Publication status	Published - 16 Aug 2012

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Baddeley, T., Clunas, S., Harrington, C. R., Horsley, D., Ishaq, A., Khan, K., Loh, Y. S., Marshall, C., Rickard, J. E., Simpson, M., Sinclair, J. P., Storey, J. M. D., Williamson, C., Wischik, C. M., & Wood, B. A. (2012). New phenothiazine diaminium compounds are tau protein aggregation inhibitors, useful to treat e.g. Alzheimer's disease, Pick's disease, progressive supranuclear palsy, frontotemporal dementia and frontotemporal lobar degeneration syndromes. (Patent No. WO2012107706-A1).

New phenothiazine diaminium compounds are tau protein aggregation inhibitors, useful to treat e.g. Alzheimer's disease, Pick's disease, progressive supranuclear palsy, frontotemporal dementia and frontotemporal lobar degeneration syndromes. / Baddeley, Thomas (Inventor); Clunas, Scott (Inventor); Harrington, Charles Robert (Inventor) et al.
Patent No.: WO2012107706-A1. Aug 16, 2012.

Research output: Patent

Baddeley, T , Clunas, S , Harrington, CR , Horsley, D, Ishaq, A, Khan, K, Loh, YS, Marshall, C, Rickard, JE, Simpson, M , Sinclair, JP , Storey, JMD, Williamson, C, Wischik, CM & Wood, BA Aug. 16 2012, New phenothiazine diaminium compounds are tau protein aggregation inhibitors, useful to treat e.g. Alzheimer's disease, Pick's disease, progressive supranuclear palsy, frontotemporal dementia and frontotemporal lobar degeneration syndromes, Patent No. WO2012107706-A1.

Baddeley, Thomas (Inventor) ; Clunas, Scott (Inventor) ; Harrington, Charles Robert (Inventor) et al. / New phenothiazine diaminium compounds are tau protein aggregation inhibitors, useful to treat e.g. Alzheimer's disease, Pick's disease, progressive supranuclear palsy, frontotemporal dementia and frontotemporal lobar degeneration syndromes. Patent No.: WO2012107706-A1. Aug 16, 2012.

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title = "New phenothiazine diaminium compounds are tau protein aggregation inhibitors, useful to treat e.g. Alzheimer's disease, Pick's disease, progressive supranuclear palsy, frontotemporal dementia and frontotemporal lobar degeneration syndromes",

abstract = "PATENT CITATIONSWO1996030766A1 Inhibition of tau-tau-associationWO2002055720A2 Materials and methods relating to protein aggregation in neurodegenerative diseaseWO2002075318A2 Neurofibrillary labelsWO2005030676A1 Methods of [11c]-radiolabelling phenothiazine and phenothiazine-like compoundsWO2007110627A2 3,7-diamino-10h-phenothiazine salts and their useWO2007110630A1 Thioninium compounds and their useWO2008007074A2 Methods of synthesis and/or purification of diaminophenothiazinium compoundsWO2008155533A2 Phenothiazine compounds for treating mild cognitive impairmentGB2007001105W GB2008002066W US4880373 Tablet pressWista Laboratories Ltd.",

author = "Thomas Baddeley and Scott Clunas and Harrington, {Charles Robert} and David Horsley and Ahtsham Ishaq and Karrar Khan and Loh, {Yin Sze} and Colin Marshall and Rickard, {Janet Elizabeth} and Michael Simpson and Sinclair, {James Peter} and Storey, {John M. D.} and Craig Williamson and Wischik, {Claude Michel} and Wood, {Barry Alan}",

year = "2012",

month = aug,

day = "16",

language = "English",

type = "Patent",

note = "WO2012107706-A1",

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TY - PAT

T1 - New phenothiazine diaminium compounds are tau protein aggregation inhibitors, useful to treat e.g. Alzheimer's disease, Pick's disease, progressive supranuclear palsy, frontotemporal dementia and frontotemporal lobar degeneration syndromes

AU - Baddeley, Thomas

AU - Clunas, Scott

AU - Harrington, Charles Robert

AU - Horsley, David

AU - Ishaq, Ahtsham

AU - Khan, Karrar

AU - Loh, Yin Sze

AU - Marshall, Colin

AU - Rickard, Janet Elizabeth

AU - Simpson, Michael

AU - Sinclair, James Peter

AU - Storey, John M. D.

AU - Williamson, Craig

AU - Wischik, Claude Michel

AU - Wood, Barry Alan

PY - 2012/8/16

Y1 - 2012/8/16

N2 - PATENT CITATIONSWO1996030766A1 Inhibition of tau-tau-associationWO2002055720A2 Materials and methods relating to protein aggregation in neurodegenerative diseaseWO2002075318A2 Neurofibrillary labelsWO2005030676A1 Methods of [11c]-radiolabelling phenothiazine and phenothiazine-like compoundsWO2007110627A2 3,7-diamino-10h-phenothiazine salts and their useWO2007110630A1 Thioninium compounds and their useWO2008007074A2 Methods of synthesis and/or purification of diaminophenothiazinium compoundsWO2008155533A2 Phenothiazine compounds for treating mild cognitive impairmentGB2007001105W GB2008002066W US4880373 Tablet pressWista Laboratories Ltd.

AB - PATENT CITATIONSWO1996030766A1 Inhibition of tau-tau-associationWO2002055720A2 Materials and methods relating to protein aggregation in neurodegenerative diseaseWO2002075318A2 Neurofibrillary labelsWO2005030676A1 Methods of [11c]-radiolabelling phenothiazine and phenothiazine-like compoundsWO2007110627A2 3,7-diamino-10h-phenothiazine salts and their useWO2007110630A1 Thioninium compounds and their useWO2008007074A2 Methods of synthesis and/or purification of diaminophenothiazinium compoundsWO2008155533A2 Phenothiazine compounds for treating mild cognitive impairmentGB2007001105W GB2008002066W US4880373 Tablet pressWista Laboratories Ltd.

M3 - Patent

M1 - WO2012107706-A1

ER -