Research output per year
Research output per year
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Dive into the research topics where Michael Simpson is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Cysteine-independent inhibition of Alzheimer's disease-like paired helical filament assembly by leuco-methylthioninium (LMT)
Al-Hilaly, Y. K., Pollack, S. J., Rickard, J. E., Simpson, M., Raulin, A.-C., Baddeley, T., Schellenberger, P., Storey, J. M. D., Harrington, C. R., Wischik, C. M. (Corresponding Author) & Serpell, L. C. (Corresponding Author), 19 Oct 2018, In: Journal of Molecular Biology. 430, 21, p. 4119-4131 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile33 Citations (Scopus)21 Downloads (Pure) -
Alzheimer's Disease-like Paired Helical Filament Assembly from Truncated Tau Protein Is Independent of Disulfide Crosslinking
Al-Hilaly, Y. K., Pollack, S. J., Vadukul, D., Citossi, F., Rickard, J. E., Simpson, M., Storey, J. M. D., Harrington, C. R., Wischik, C. M. & Serpell, L. C., 24 Nov 2017, In: Journal of Molecular Biology. 429, 23, p. 3650-3665 16 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile65 Citations (Scopus)27 Downloads (Pure) -
Cellular Models of Aggregation-Dependent Template-Directed Proteolysis to Characterize Tau Aggregation Inhibitors for Treatment of Alzheimer's Disease
Harrington, C. R., Storey, J. M. D., Clunas, S., Harrington, K. A., Horsley, D., Ishaq, A., Kemp, S. J., Larch, C. P., Marshall, C., Nicoll, S. L., Rickard, J. E., Simpson, M., Sinclair, J. P., Storey, L. J. & Wischik, C. M., 24 Apr 2015, In: The Journal of Biological Chemistry. 290, 17, p. 10862-10875 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile82 Citations (Scopus)24 Downloads (Pure) -
New phenothiazine diaminium compounds are tau protein aggregation inhibitors, useful to treat e.g. Alzheimer's disease, Pick's disease, progressive supranuclear palsy, frontotemporal dementia and frontotemporal lobar degeneration syndromes
Baddeley, T. (Inventor), Clunas, S. (Inventor), Harrington, C. R. (Inventor), Horsley, D. (Inventor), Ishaq, A. (Inventor), Khan, K. (Inventor), Loh, Y. S. (Inventor), Marshall, C. (Inventor), Rickard, J. E. (Inventor), Simpson, M. (Inventor), Sinclair, J. P. (Inventor), Storey, J. M. D. (Inventor), Williamson, C. (Inventor), Wischik, C. M. (Inventor) & Wood, B. A. (Inventor), 16 Aug 2012, Patent No. WO2012107706-A1, Priority date 11 Feb 2011Research output: Patent
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Development of 18F-fluorinatable dendrons and their application to cancer cell targeting
Trembleau, L., Simpson, M., Cheyne, R. W., Escofet, I., Appleyard, M. V. C. L., Murray, K., Sharp, S., Thompson, A. M. & Smith, T. A. D., Nov 2011, In: New Journal of Chemistry. 35, 11, p. 2496-2502 7 p.Research output: Contribution to journal › Article › peer-review
27 Citations (Scopus)