One-pot production of 18F-biotin by conjugation with 18F-FDG for pre-targeted imaging: Synthesis and radio-labelling of a PEGylated precursor

Michael Simpson; Laurent Alain Claude Trembleau; Richard, W. Cheyne; Timothy Andrew Davies Smith

doi:10.1016/j.apradiso.2010.10.012

One-pot production of 18F-biotin by conjugation with 18F-FDG for pre-targeted imaging: Synthesis and radio-labelling of a PEGylated precursor

Michael Simpson, Laurent Alain Claude Trembleau, Richard, W. Cheyne, Timothy Andrew Davies Smith

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Abstract

The biotin-avidin affinity system is exploited in pre-targeted imaging using avidin-conjugated antibodies. 18F-FDG is available at all PET centres. 18F-FDG forms oximes by reaction with oxyamine. Herein we describe the synthesis of oxyamine-funtionalised biotin, its 18F-labelling by conjugation with 18F-FDG and confirm its ability to interact with avidin. © 2010 Elsevier Ltd.

Original language	English
Pages (from-to)	418-422
Number of pages	5
Journal	Applied Radiation and Isotopes
Volume	69
Issue number	2
Early online date	27 Oct 2010
DOIs	https://doi.org/10.1016/j.apradiso.2010.10.012
Publication status	Published - Feb 2011

Keywords

18F-FDG
Biotin
Avidin
Pre-target

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10.1016/j.apradiso.2010.10.012

One-pot production of 18F-biotin by conjugation with 18F-FDG for pre-targeted imagingAccepted author manuscript, 141 KB

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abstract = "The biotin-avidin affinity system is exploited in pre-targeted imaging using avidin-conjugated antibodies. 18F-FDG is available at all PET centres. 18F-FDG forms oximes by reaction with oxyamine. Herein we describe the synthesis of oxyamine-funtionalised biotin, its 18F-labelling by conjugation with 18F-FDG and confirm its ability to interact with avidin. {\textcopyright} 2010 Elsevier Ltd. ",

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AU - Simpson, Michael

AU - Trembleau, Laurent Alain Claude

AU - Cheyne, Richard, W.

AU - Smith, Timothy Andrew Davies

PY - 2011/2

Y1 - 2011/2

N2 - The biotin-avidin affinity system is exploited in pre-targeted imaging using avidin-conjugated antibodies. 18F-FDG is available at all PET centres. 18F-FDG forms oximes by reaction with oxyamine. Herein we describe the synthesis of oxyamine-funtionalised biotin, its 18F-labelling by conjugation with 18F-FDG and confirm its ability to interact with avidin. © 2010 Elsevier Ltd.

AB - The biotin-avidin affinity system is exploited in pre-targeted imaging using avidin-conjugated antibodies. 18F-FDG is available at all PET centres. 18F-FDG forms oximes by reaction with oxyamine. Herein we describe the synthesis of oxyamine-funtionalised biotin, its 18F-labelling by conjugation with 18F-FDG and confirm its ability to interact with avidin. © 2010 Elsevier Ltd.

KW - 18F-FDG

KW - Biotin

KW - Avidin

KW - Pre-target

U2 - 10.1016/j.apradiso.2010.10.012

DO - 10.1016/j.apradiso.2010.10.012

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IS - 2

ER -

One-pot production of 18F-biotin by conjugation with 18F-FDG for pre-targeted imaging: Synthesis and radio-labelling of a PEGylated precursor

Abstract

Keywords

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