Oxidative stress, malaria, sickle cell disease, and innate immunity

Huan Cao, Mark Vickers* (Corresponding Author)

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)
4 Downloads (Pure)


Plasmodium falciparum shields from adaptive immunity in erythrocytes, but how might the innate immune system recognize infected cells? Replication by the parasite results in oxidative stress, causing surface expression of high-mannose glycans. These can act as pathogen-associated molecular patterns to stimulate phagocytosis in the spleen and the sickle cell allele enhances these responses.
Original languageEnglish
Pages (from-to)849-851
Number of pages3
JournalTrends in Immunology
Issue number10
Early online date30 Sept 2021
Publication statusPublished - 1 Dec 2021

Bibliographical note

This work was supported by the Wellcome Trust (grant 094847).


  • malaria
  • sickle cell disease
  • oxidative stress
  • high mannose glycans
  • pathogen associated molecular patterns
  • damage associated molecular pattern
  • phagocytosis


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