Plasmodium falciparum shields from adaptive immunity in erythrocytes, but how might the innate immune system recognize infected cells? Replication by the parasite results in oxidative stress, causing surface expression of high-mannose glycans. These can act as pathogen-associated molecular patterns to stimulate phagocytosis in the spleen and the sickle cell allele enhances these responses.
Bibliographical noteThis work was supported by the Wellcome Trust (grant 094847).
- sickle cell disease
- oxidative stress
- high mannose glycans
- pathogen associated molecular patterns
- damage associated molecular pattern