Roles of long noncoding RNAs and small extracellular vesicle-long noncoding RNAs in type 2 diabetes

Wenguang Chang* (Corresponding Author), Man Wang, Yuan Zhang, Fei Yu, Bin Hu, Katarzyna Goljanek-Whysall, Peifeng Li

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

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The prevalence of a high-energy diet and a sedentary lifestyle has increased the incidence of type 2 diabetes (T2D). T2D is a chronic disease characterized by
high blood glucose levels and insulin resistance in peripheral tissues. The pathological mechanism of this disease is not fully clear. Accumulated evidence has
shown that noncoding RNAs have an essential regulatory role in the progression of diabetes and its complications. The roles of small noncoding RNAs, such as
miRNAs, in T2D, have been extensively investigated, while the function of long noncoding RNAs (lncRNAs) in T2D has been unstudied. It has been reported that
lncRNAs in T2D play roles in the regulation of pancreatic function, peripheral glucose homeostasis and vascular inflammation. In addition, lncRNAs carried by
small extracellular vesicles (sEV) were shown to mediate communication between organs and participate in diabetes progression. Some sEV lncRNAs derived from
stem cells are being developed as potential therapeutic agents for diabetic complications. In this review, we summarize the current knowledge relating to
lncRNA biogenesis, the mechanisms of lncRNA sorting into sEV and the regulatory roles of lncRNAs and sEV lncRNAs in diabetes. Knowledge of lncRNAs and sEV lncRNAs in diabetes will aid in the development of new therapeutic drugs for T2D in the future.
Original languageEnglish
Pages (from-to)526-537
Number of pages12
Issue number11
Early online date26 Sept 2022
Publication statusPublished - 18 Oct 2022

Bibliographical note

Wenguang Chang, Man Wang, Yuan Zhang and Fei Yu collected all of the data, and Wenguang Chang, Bin Hu, Katarzyna Goljanek-Whysall and Peifeng Li wrote and revised the manuscript. All authors have read and approved the final version of the manuscript.
This work was supported by National Natural Science Foundation of China (81700704).

Data Availability Statement

The peer review history for this article is available at
Data sharing is not applicable to this article as no new data were created or analyzed in this study.


  • diabetes
  • exosomes
  • long noncoding RNA
  • small extracellular vesicle
  • sorting mechanism


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