Marine Biodiscovery Centre

Research output

Research output per year 2018 2021 2022 2023 2023

• 13 Article

Research output per year

Research output per year

Search results

• 2023

  Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors

  Boby, M. L., Fearon, D., Ferla, M., Filep, M., Koekemoer, L., Robinson, M. C., COVID Moonshot Consortium, Chodera, J. D., Lee, A. A., London, N., von Delft, A. & von Delft, F., 10 Nov 2023, In: Science (New York, N.Y.). 382, 6671, 17 p., eabo7201.

  Research output: Contribution to journal › Article › peer-review

  • Severe Acute Respiratory Syndrome 100%
  • Coronavirus 97%
  • Protease Inhibitors 80%
  • Antiviral Agents 66%
  • Pandemics 30%
  12 Citations (Scopus)

• Discovery and structural assignment of (S)-sydosine from amphipod-derived Aspergillus sydowii MBC15-11F through HRMS, advanced Mosher and molecular modelling analyses

  Qader, M., Mweetwa, L. L., Rämä, T., Thissera, B., Milne, B. F., Abdelmohsen, U. R., Orfali, R., Tawfike, A., Esheli, M., Oluwabusola, E. T., Jaysainghe, L., Jaspars, M. & Rateb, M. E., Aug 2023, In: Journal of Applied Microbiology. 134, 8, 12 p., lxad158.

  Research output: Contribution to journal › Article › peer-review

  • Amphipoda 100%
  • phenamide 72%
  • Aspergillus 63%
  • Fermentation 59%
  • Molecular Structure 33%

• First-principles study of electronic and optical properties in 1-dimensional oligomeric derivatives of telomestatin

  Mérgola-Greef, J. & Milne, B. F., 24 Apr 2023, In: Physical Chemistry Chemical Physics. 25, 18, p. 12744-12753 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Telomestatin 100%
  • oligomers 62%
  • Electronic Property 44%
  • Oligomer 43%
  • Optical Property 39%
  3 Downloads (Pure)

• Arabinofuranosyl Thymine Derivatives—Potential Candidates against Cowpox Virus: A Computational Screening Study

  Hasan, A. H., Preet, G., Milne, B. F., Ebel, R. & Jaspars, M., 16 Jan 2023, In: International Journal of Molecular Sciences. 24, 2, 1751.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cowpox 100%
  • Cowpox virus 92%
  • thymine 79%
  • Thymine 76%
  • viruses 67%
  11 Downloads (Pure)

• Antiparasitic Activities of Compounds Isolated from Aspergillus fumigatus Strain Discovered in Northcentral Nigeria

  Diyaolu, O. A., Preet, G., Fagbemi, A. A., Annang, F., Pérez-Moreno, G., Bosch-Navarrete, C., Adebisi, O. O., Oluwabusola, E. T., Milne, B. F., Jaspars, M. & Ebel, R., Jan 2023, In: Antibiotics. 12, 1, 16 p., 109.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Antiparasitic Agents 100%
  • Aspergillus fumigatus 90%
  • pseurotin 78%
  • Nigeria 77%
  • Fumitremorgin C 71%
  3 Citations (Scopus)

  5 Downloads (Pure)
• 2022

  Computational Repurposing of Mitoxantrone-Related Structures against Monkeypox Virus: A Molecular Docking and 3D Pharmacophore Study

  Preet, G., Oluwabusola, E. T., Milne, B. F., Ebel, R. & Jaspars, M., 18 Nov 2022, In: International Journal of Molecular Sciences. 23, 22, 15 p., 14287.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Monkeypox 100%
  • Monkeypox virus 99%
  • Mitoxantrone 86%
  • viruses 69%
  • Viruses 68%
  11 Citations (Scopus)

  6 Downloads (Pure)

• Mutactimycin AP, a New Mutactimycin Isolated from an Actinobacteria from the Atacama Desert

  Astakala, R. V., Preet, G., Milne, B., Tibyangye, J., Razmilic, V., Castro, J. F., Asenjo, J. A., Andrews, B., Ebel, R. & Jaspars, M., 1 Nov 2022, In: Molecules. 27, 21, 12 p., 7185.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • deserts 100%
  • antibiotics 97%
  • Actinobacteria 89%
  • Antimicrobial Agent 49%
  • Anti-Bacterial Agents 46%
  1 Downloads (Pure)

• A ribosomally synthesised and post-translationally modified peptide containing a β-enamino acid and a macrocyclic motif

  Wang, S., Lin, S., Fang, Q., Gyampoh, R., Lu, Z., Gao, Y., Clarke, D. J., Wu, K., Trembleau, L., Yu, Y., Kyeremeh, K., Milne, B. F., Tabudravu, J. & Deng, H., 26 Aug 2022, In: Nature Communications. 13, 1, 15 p., 5044.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • peptides 100%
  • Sulfides 81%
  • acids 80%
  • Dehydroamino Acid 70%
  • Acids 68%
  11 Citations (Scopus)

  1 Downloads (Pure)

• SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids

  Jansen, J., Reimer, K. C., Nagai, J. S., Varghese, F. S., Overheul, G. J., de Beer, M., Roverts, R., Daviran, D., Fermin, L. A. S., Willemsen, B., Beukenboom, M., Djudjaj, S., von Stillfried, S., van Eijk, L. E., Mastik, M., Bulthuis, M., Dunnen, W. D., van Goor, H., Hillebrands, J-L., Triana, S. H., & 187 othersAlexandrov, T., Timm, M-C., van den Berge, B. T., van den Broek, M., Nlandu, Q., Heijnert, J., Bindels, E. M. J., Hoogenboezem, R. M., Mooren, F., Kuppe, C., Miesen, P., Grünberg, K., Ijzermans, T., Steenbergen, E. J., Czogalla, J., Schreuder, M. F., Sommerdijk, N., Akiva, A., Boor, P., Puelles, V. G., Floege, J., Huber, T. B., Achdout, H., Aimon, A., Bar-David, E., Barr, H., Ben-Shmuel, A., Bennett, J., Boby, M. L., Borden, B., Bowman, G. R., Brun, J., BVNBS, S., Calmiano, M., Carbery, A., Cattermole, E., Chernychenko, E., Choder, J. D., Clyde, A., Coffland, J. E., Cohen, G., Cole, J., Contini, A., Cox, L., Cvitkovic, M., Dias, A., Donckers, K., Dotson, D. L., Douangamath, A., Duberstein, S., Dudgeon, T., Dunnett, L., Eastman, P. K., Erez, N., Eyermann, C. J., Fairhead, M., Fate, G., Fearon, D., Federov, O., Ferla, M., Fernandes, R. S., Ferrins, L., Foster, R., Foster, H., Gabizon, R., Garcia-Sastre, A., Gawriljuk, V. O., Gehrtz, P., Gileadi, C., Giroud, C., Glass, W. G., Glen, R., glinert, I., Godoy, A. S., Gorichko, M., Gorrie-Stone, T., Griffen, E. J., Hart, S. H., Heer, J., Henry, M., Hill, M., Horrell, S., Hurley, M. F. D., Israely, T., Jajack, A., Jnoff, E., Jochmans, D., John, T., De Jonghe, S., Kantsadi, A. L., Kenny, P. W., Kiappes, J. L., Koekemoer, L., Kovar, B., Krojer, T., Lee, A. A., Lefker, B. A., Levy, H., London, N., Lukacik, P., Macdonald, H. B., Maclean, B., Malla, T. R., Matviiuk, T., McCorkindale, W., McGovern, B. L., Melamed, S., Michurin, O., Mikolajek, H., Milne, B. F., Morris, A., Morris, G. M., Morwitzer, M. J., Moustakas, D., Nakamura, A. M., Neto, J. B., Neyts, J., Nguyen, L., Noske, G. D., Oleinikovas, V., Oliva, G., Owen, D., Psenak, V., Pai, R., Pan, J., Paran, N., Perry, B., Pingle, M., Pinjari, J., Politi, B., Powell, A., Puni, R., Rangel, V. L., Reddi, R. N., Reid, S. P., Resnick, E., Ripka, E. G., Robinson, M. C., Robinson, R. P., Rodriguez-Guerra, J., Rosales, R., Rufa, D., Schofield, C., Shafeev, M., Shaikh, A., Shi, J., Shurrush, K., Sing, S., Sittner, A., Skyner, R., Smalley, A., Smilova, M. D., Solmesky, L. J., Spencer, J., Strain-Damarell, C., Swamy, V., Tamir, H., Tennant, R., Thompson, W., Thompson, A., Tomasia, S., Tumber, A., Vakonakis, I., van Rij, R. P., van Geel, L., Vaschetto, M., Vitner, E. B., Voelz, V., Volkamer, A., von Delft, F., von Delft, A., Walsh, M., Ward, W., Weatherall, C., Weiss, S., White, K. M., Wild, C. F., Wittmann, M., Wright, N., Yahalom-Ronen, Y., Zaidmann, D., Zidane, H., Zitzmann, N., Costa, I. G., Schneider, R. K., Smeets, B. & Kramann, R., 3 Feb 2022, In: Cell Stem Cell. 29, 2, p. 217-231.e8 24 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • SARS Virus 100%
  • Organoids 89%
  • Fibrosis 50%
  • Kidney 36%
  • Cell Dedifferentiation 17%
  135 Citations (Scopus)

  2 Downloads (Pure)
• 2021

  First-principles characterisation of spectroscopic and bonding properties of cationic bismuth carbide clusters

  Almeida, D. A. F., Oliveira, M. J. T. & Milne, B. F., 1 Oct 2021, In: Computational and Theoretical Chemistry. 1204, 1 p., 113372.

  Research output: Contribution to journal › Article › peer-review

  • Bismuth 100%
  • bismuth 70%
  • carbides 69%
  • Density Functional Theory 62%
  • Molecular Cluster 46%

• New insights on Laminaria digitata ultrastructure through combined conventional chemical fixation and cryofixation

  Katsaros, C. I., Le Panse, S., Milne, G., Carrano, C. J. & Kuepper, F., 25 Jun 2021, In: Botanica Marina. 64, 3, p. 177-187

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Laminaria digitata 100%
  • ultrastructure 77%
  • cryopreservation 67%
  • fixation 65%
  • vegetative cells 50%
  3 Citations (Scopus)

  8 Downloads (Pure)

• Dermacozine N, the First Natural Linear Pentacyclic Oxazinophenazine with UV–Vis Absorption Maxima in the Near Infrared Region, along with Dermacozines O and P Isolated from the Mariana Trench Sediment Strain Dermacoccus abyssi MT 1.1 T

  Juhasz, B., Pech-Puch, D., Tabudravu, J. N., Cautain, B., Reyes, F., Jiménez, C., Kyeremeh, K. & Jaspars, M., 3 Jun 2021, In: Marine Drugs. 19, 6, 22 p., e325.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • phenoxazine 100%
  • Phenoxazine 74%
  • Absorption Maxima 49%
  • Density Functional Theory 44%
  • Linear Models 40%
  3 Citations (Scopus)

  6 Downloads (Pure)
• 2018

  N-Prenylation of Tryptophan by an Aromatic Prenyltransferase from the Cyanobactin Biosynthetic Pathway

  Dalponte, L., Parajuli, A., Younger, E., Mattila, A., Jokela, J., Wahlsten, M., Leikoski, N., Sivonen, K., Jarmusch, S. A., Houssen, W. E. & Fewer, D. P., 2018, In: Biochemistry. 57, 50, p. 6860-6867 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • cyanobactins 100%
  • Dimethylallyltranstransferase 76%
  • Prenylation 62%
  • Biosynthetic Pathways 53%
  • Tryptophan 47%
  22 Citations (Scopus)

  20 Downloads (Pure)