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James Sinclair
Dr
Senior Research Fellow
,
Natural & Computing Sciences
,
Chemistry
138
Citations
2004
2015
Research activity per year
Overview
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Research output
(11)
Impacts
(1)
Similar Profiles
(12)
Research output
Research output per year
2004
2006
2015
2015
6
Patent
5
Article
Research output per year
Research output per year
6 results
Publication Year, Title
(descending)
Publication Year, Title
(ascending)
Title
Type
Filter
Patent
Search results
2015
Making thiosulfate-disubstituted-amino-optionally substituted-phenyl-imino-optionally substituted-cyclohexadienylidene-N,N-disubstituted-ammoniums comprises carrying out nitrosyl reduction, thiosulfonic acid formation and oxidative coupling
Sinclair, J. P.
,
Nicoll, S. L.
&
Storey, J. M. D.
,
16 Apr 2015
, Patent No. WO2015052496 A1, Priority date
7 Oct 2013
Research output
:
Patent
Chloride
100%
Reduction
77%
Methylene Blue
74%
Acid
59%
2012
New phenothiazine diaminium compounds are tau protein aggregation inhibitors, useful to treat e.g. Alzheimer's disease, Pick's disease, progressive supranuclear palsy, frontotemporal dementia and frontotemporal lobar degeneration syndromes
Baddeley, T.
,
Clunas, S.
,
Harrington, C. R.
,
Horsley, D.
,
Ishaq, A.
,
Khan, K.
,
Loh, Y. S.
,
Marshall, C.
,
Rickard, J. E.
,
Simpson, M.
,
Sinclair, J. P.
,
Storey, J. M. D.
,
Williamson, C.
,
Wischik, C. M.
&
Wood, B. A.
,
16 Aug 2012
, Patent No. WO2012107706-A1, Priority date
11 Feb 2011
Research output
:
Patent
Pick Disease of the Brain
100%
phenothiazine
94%
Frontotemporal Lobar Degeneration
92%
Progressive Supranuclear Palsy
88%
tau Proteins
82%
2011
3,7-diamino-10H-phenothiazine salts and their use: WO2007110627
Wischik, C. M.
,
Rickard, J. E.
,
Harrington, C. R.
,
Horsley, D.
,
Storey, J. M. D.
,
Marshall, C.
,
Sinclair, J. P.
&
Baddeley, T.
,
15 Feb 2011
, Patent No. US7,888,350
Research output
:
Patent
File
phenothiazine
100%
Salts
61%
Tauopathies
31%
Prodrugs
25%
Chlorides
24%
19
Downloads (Pure)
2010
Methods of chemical synthesis and purification of diaminophenothiazinium compounds including methylthioninium chloride (MTC): methods of treatment of a tauopathy condition comprising the use of thioninium compounds
Wischik, C. M.
,
Rickard, J. E.
,
Harrington, C. R.
,
Horsley, D.
,
Storey, J. M. D.
,
Marshall, C.
&
Sinclair, J. P.
,
15 Jun 2010
, Patent No. US7,737,138
Research output
:
Patent
Dimethyldithiocarbamate
100%
Purification
86%
Chloride Salt
78%
Ethylenediaminetetraacetic Acid
74%
Chloride
74%
2009
Methods of synthesis and/or purification of diaminophenothiazinium compounds
Wischik, C. M.
,
Storey, J. M. D.
,
Marshall, C.
,
Sinclair, J. P.
&
Baddeley, T.
,
2009
, Patent No. EP2057136
Research output
:
Patent
2006
Methods of chemical synthesis and purification of diaminophenothiazinium compounds including methylthioninium chloride (MTC)
Storey, J. M. D.
,
Sinclair, J. P.
,
Marshall, C.
,
Tan, H. W.
&
Wischik, C. M.
,
2006
, Patent No. WO 2006/032879 Filed 23.09.04. Published 30 March 2006.
Research output
:
Patent