Economic evaluation of surgical treatments for women with stress urinary incontinence: a cost-utility and value of information analysis

Mehdi Javanbakht, Eoin Moloney* (Corresponding Author), Miriam Brazzelli, Sheila Wallace, Laura Ternent, Muhammad Imran Omar, Ash Monga, Lucky Saraswat, Phil Mackie, Frauke Becker, Mari Imamura, Jemma Hudson, Michal Shimonovich, Graeme MacLennan, Luke Vale, Dawn Craig

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)
5 Downloads (Pure)


Objectives Stress urinary incontinence (SUI) and stress-predominant mixed urinary incontinence (MUI) are common conditions that can have a negative impact on the quality of life of patients and serious cost implications for healthcare providers. The objective of this study was to assess the cost-effectiveness of nine different surgical interventions for treatment of SUI and stress-predominant MUI from a National Health Service and personal social services perspective in the UK.

Methods A Markov microsimulation model was developed to compare the costs and effectiveness of nine surgical interventions. The model was informed by undertaking a systematic review of clinical effectiveness and network meta-analysis. The main clinical parameters in the model were the cure and incidence rates of complications after different interventions. The outcomes from the model were expressed in terms of cost per quality-adjusted life-years (QALYs) gained. In addition, expected value of perfect information (EVPI) analyses were conducted to quantify the main uncertainties facing decision-makers.

Results The base-case results suggest that retropubic mid-urethral sling (retro-MUS) is the most cost-effective surgical intervention over a 10-year and lifetime time horizon. The probabilistic results show that retro-MUS and traditional sling are the interventions with the highest probability of being cost-effective across all willingness-to-pay thresholds over a lifetime time horizon. The value of information analysis results suggest that the largest value appears to be in removing uncertainty around the incidence rates of complications, the relative treatment effectiveness and health utility values.

Conclusions Although retro-MUS appears, at this stage, to be a cost-effective intervention, research is needed on possible long-term complications of all surgical treatments to provide reassurance of safety, or earlier warning of unanticipated adverse effects. The value of information analysis supports the need, as a first step, for further research to improve our knowledge of the actual incidence of complications.
Original languageEnglish
Article number035555
Number of pages8
JournalBMJ Open
Issue number6
Early online date11 Jun 2020
Publication statusPublished - 2020

Bibliographical note

We would like to acknowledge all those involved in the wider study exploring the effectiveness and cost-effectiveness of surgical treatments for women with stress urinary incontinence.
Funding: This research was commissioned by the NIHR HTA Programme as project number 15/09/06. The views expressed are those of the authors and not necessarily those of the NHS, the NIHR or the Department of Health and Social Care, UK. The funders were not actively involved in the research process at any stage. The study design, collection, analysis and interpretation of data, the writing of the manuscript and the decision to submit it for publication were all performed independent of the funders.


  • adult surgery
  • health economics
  • urinary incontinences


Dive into the research topics of 'Economic evaluation of surgical treatments for women with stress urinary incontinence: a cost-utility and value of information analysis'. Together they form a unique fingerprint.

Cite this