The effects of graded levels of calorie restriction XV: phase space attractors reveal distinct behavioral phenotypes

Deshun Sun; Fei Liu; Sharon E Mitchell; Huanfei Ma; Davina Derous; Yingchun Wang; Jackie J.D. Han; Promislow, Daniel E.L.; David Lusseau; Alex Douglas; John R Speakman; Luonan Chen

doi:10.1093/gerona/glaa055

The effects of graded levels of calorie restriction XV: phase space attractors reveal distinct behavioral phenotypes

Deshun Sun^* (Corresponding Author), Fei Liu, Sharon E Mitchell, Huanfei Ma, Davina Derous, Yingchun Wang, Jackie J.D. Han, Promislow, Daniel E.L., David Lusseau, Alex Douglas, John R Speakman, Luonan Chen

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

5 Downloads (Pure)

Abstract

Calorie restriction (CR) has a positive impact on health and lifespan. Previous work however does not reveal the whole underlying mechanism of bahavioral phenotypes under CR. We propose a new approach based on phase space reconstruction (PSR) to analyze the bahavioral responses of mice to graded CR. This involved reconstructing high-dimensional attractors which topologically represent the intrinsic dynamics of mice based on low-dimensional time series of movement counts observed during the 90 day time course of restriction. PSR together with correlation dimensions (CD), Kolmogorov entropy (KE) and multifractal spectra builds a map from internal attractors to the phenotype of mice and reveals the mice with increasing CR levels undergo significant changes from a normal to a new state. Features of the attractors (CD and KE) were significantly associated with gene expression profiles in the hypothalamus of the same individuals.

Original language	English
Pages (from-to)	858-866
Number of pages	9
Journal	The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Volume	75
Issue number	5
Early online date	4 Mar 2020
DOIs	https://doi.org/10.1093/gerona/glaa055
Publication status	Published - May 2020

Bibliographical note

Keywords

calorie restriction
phase space reconstruction
attractors
gene expression
Phase space reconstruction
Calorie restriction
Attractors
Gene expression
MORTALITY
PROTEIN RESTRICTION
BODY-TEMPERATURE
KOLMOGOROV-ENTROPY
TRANSCRIPTOMIC RESPONSES
IMPACT
SHORT-TERM CALORIE
TIME-SERIES
PHYSICAL-ACTIVITY
LIFE

Access to Document

10.1093/gerona/glaa055Licence: Unspecified

Sun_etal_Effects_AAM
This is a pre-copyedited, author-produced version of an article accepted for publication in Journals of Gerontology, Series A following peer review. The version of record Deshun Sun, PhD, Fei Liu, PhD, Sharon E Mitchell, PhD, Huanfei Ma, PhD, Davina Derous, PhD, Yingchun Wang, PhD, Jackie J D Han, PhD, Daniel E L Promislow, PhD, David Lusseau, PhD, Alex Douglas, PhD, John R Speakman, PhD, Luonan Chen, PhD, The Effects of Graded Levels of Calorie Restriction XV: Phase Space Attractors Reveal Distinct Behavioral Phenotypes, The Journals of Gerontology: Series A, Volume 75, Issue 5, May 2020, Pages 858–866, is available online at: https://academic.oup.com/biomedgerontology/article/75/5/858/5780099 or https://doi.org/10.1093/gerona/glaa055
Accepted author manuscript, 349 KBLicence: Unspecified

Cite this

Sun, D., Liu, F., Mitchell, S. E., Ma, H., Derous, D., Wang, Y., Han, J. J. D., Daniel E.L., P., Lusseau, D., Douglas, A., Speakman, J. R., & Chen, L. (2020). The effects of graded levels of calorie restriction XV: phase space attractors reveal distinct behavioral phenotypes. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 75(5), 858-866. https://doi.org/10.1093/gerona/glaa055

The effects of graded levels of calorie restriction XV: phase space attractors reveal distinct behavioral phenotypes. / Sun, Deshun (Corresponding Author); Liu, Fei; Mitchell, Sharon E et al.
In: The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, Vol. 75, No. 5, 05.2020, p. 858-866.

Research output: Contribution to journal › Article › peer-review

Sun, D, Liu, F, Mitchell, SE, Ma, H, Derous, D, Wang, Y, Han, JJD, Daniel E.L., P, Lusseau, D , Douglas, A , Speakman, JR & Chen, L 2020, 'The effects of graded levels of calorie restriction XV: phase space attractors reveal distinct behavioral phenotypes', The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, vol. 75, no. 5, pp. 858-866. https://doi.org/10.1093/gerona/glaa055

@article{38896e52cc3d40769ff0af8adf57708e,

title = "The effects of graded levels of calorie restriction XV: phase space attractors reveal distinct behavioral phenotypes",

abstract = "Calorie restriction (CR) has a positive impact on health and lifespan. Previous work however does not reveal the whole underlying mechanism of bahavioral phenotypes under CR. We propose a new approach based on phase space reconstruction (PSR) to analyze the bahavioral responses of mice to graded CR. This involved reconstructing high-dimensional attractors which topologically represent the intrinsic dynamics of mice based on low-dimensional time series of movement counts observed during the 90 day time course of restriction. PSR together with correlation dimensions (CD), Kolmogorov entropy (KE) and multifractal spectra builds a map from internal attractors to the phenotype of mice and reveals the mice with increasing CR levels undergo significant changes from a normal to a new state. Features of the attractors (CD and KE) were significantly associated with gene expression profiles in the hypothalamus of the same individuals.",

keywords = "calorie restriction, phase space reconstruction, attractors, gene expression, Phase space reconstruction, Calorie restriction, Attractors, Gene expression, MORTALITY, PROTEIN RESTRICTION, BODY-TEMPERATURE, KOLMOGOROV-ENTROPY, TRANSCRIPTOMIC RESPONSES, IMPACT, SHORT-TERM CALORIE, TIME-SERIES, PHYSICAL-ACTIVITY, LIFE",

author = "Deshun Sun and Fei Liu and Mitchell, {Sharon E} and Huanfei Ma and Davina Derous and Yingchun Wang and Han, {Jackie J.D.} and {Daniel E.L.}, Promislow, and David Lusseau and Alex Douglas and Speakman, {John R} and Luonan Chen",

note = "{\textcopyright} The Author(s) 2020. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.",

year = "2020",

month = may,

doi = "10.1093/gerona/glaa055",

language = "English",

volume = "75",

pages = "858--866",

journal = "The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences",

issn = "1079-5006",

publisher = "OXFORD UNIV PRESS INC",

number = "5",

}

TY - JOUR

T1 - The effects of graded levels of calorie restriction XV

T2 - phase space attractors reveal distinct behavioral phenotypes

AU - Sun, Deshun

AU - Liu, Fei

AU - Mitchell, Sharon E

AU - Ma, Huanfei

AU - Derous, Davina

AU - Wang, Yingchun

AU - Han, Jackie J.D.

AU - Daniel E.L., Promislow,

AU - Lusseau, David

AU - Douglas, Alex

AU - Speakman, John R

AU - Chen, Luonan

PY - 2020/5

Y1 - 2020/5

N2 - Calorie restriction (CR) has a positive impact on health and lifespan. Previous work however does not reveal the whole underlying mechanism of bahavioral phenotypes under CR. We propose a new approach based on phase space reconstruction (PSR) to analyze the bahavioral responses of mice to graded CR. This involved reconstructing high-dimensional attractors which topologically represent the intrinsic dynamics of mice based on low-dimensional time series of movement counts observed during the 90 day time course of restriction. PSR together with correlation dimensions (CD), Kolmogorov entropy (KE) and multifractal spectra builds a map from internal attractors to the phenotype of mice and reveals the mice with increasing CR levels undergo significant changes from a normal to a new state. Features of the attractors (CD and KE) were significantly associated with gene expression profiles in the hypothalamus of the same individuals.

AB - Calorie restriction (CR) has a positive impact on health and lifespan. Previous work however does not reveal the whole underlying mechanism of bahavioral phenotypes under CR. We propose a new approach based on phase space reconstruction (PSR) to analyze the bahavioral responses of mice to graded CR. This involved reconstructing high-dimensional attractors which topologically represent the intrinsic dynamics of mice based on low-dimensional time series of movement counts observed during the 90 day time course of restriction. PSR together with correlation dimensions (CD), Kolmogorov entropy (KE) and multifractal spectra builds a map from internal attractors to the phenotype of mice and reveals the mice with increasing CR levels undergo significant changes from a normal to a new state. Features of the attractors (CD and KE) were significantly associated with gene expression profiles in the hypothalamus of the same individuals.

KW - calorie restriction

KW - phase space reconstruction

KW - attractors

KW - gene expression

KW - Phase space reconstruction

KW - Calorie restriction

KW - Attractors

KW - Gene expression

KW - MORTALITY

KW - PROTEIN RESTRICTION

KW - BODY-TEMPERATURE

KW - KOLMOGOROV-ENTROPY

KW - TRANSCRIPTOMIC RESPONSES

KW - IMPACT

KW - SHORT-TERM CALORIE

KW - TIME-SERIES

KW - PHYSICAL-ACTIVITY

KW - LIFE

UR - http://www.scopus.com/inward/record.url?scp=85083911813&partnerID=8YFLogxK

U2 - 10.1093/gerona/glaa055

DO - 10.1093/gerona/glaa055

M3 - Article

C2 - 32128585

SN - 1079-5006

VL - 75

SP - 858

EP - 866

JO - The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences

JF - The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences

IS - 5

ER -

The effects of graded levels of calorie restriction XV: phase space attractors reveal distinct behavioral phenotypes

Abstract

Bibliographical note

Keywords

Access to Document

Other files and links

Fingerprint

Iain Fraser Cytometry Centre

Cite this

The effects of graded levels of calorie restriction XV: phase space attractors reveal distinct behavioral phenotypes

Abstract

Bibliographical note

Keywords

Access to Document

Other files and links

Fingerprint

Equipment

Iain Fraser Cytometry Centre

Cite this