Life Sciences & Medicine

2024

Indirect genetic effects increase the heritable variation available to selection and are largest for behaviours: a meta-analysis

Santostefano, F., Moiron, M., Sánchez-Tójar, A. & Fisher, D., 26 Jul 2024, bioRxiv, 38 p.

Research output: Working paper › Preprint

Open Access

TORC1-containing signaling endosomes source membrane from vacuoles

Muneshige, K. & Hatakeyama, R., 3 Jul 2024, bioRxiv.

Research output: Working paper › Preprint

Open Access

Improving the quality, speed and transparency of curating data to the Observational Medical Outcomes Partnership (OMOP) Common Data Model using the Carrot tool (Preprint)

Cox, S., Masood, E., Panagi, V., Macdonald, C., Milligan, G., Horban, S., Santos, R., Hall, C., Lea, D., Tarr, S., Mumtaz, S., Akashili, E., Rae, A., Cole, C., Sheikh, S. A., Jefferson, E. & Quinlan, P. R., 28 Jun 2024, JMIR Publications Inc.

Research output: Working paper › Preprint

Open Access

User and developer views on using Artificial Intelligence technologies to facilitate the early diagnosis of skin cancers in primary care settings: A qualitative study (Preprint): A qualitative study (Preprint)

Jones, O. T., Calanzani, N., Scott, S. E., Matin, R. N., Emery, J. & Walter, F. M., 20 May 2024, JMIR Publications Inc., 43 p.

Research output: Working paper › Preprint

Open Access

Impact of COVID-19 on diabetes mellitus outcomes and care in sub-Saharan Africa: A scoping review

Sseguya, W., Bahendeka, S., MacLennan, S., Mody, N. & Guntupalli, A. M., 13 Apr 2024, MedRxiv.

Research output: Working paper › Preprint

Open Access

Land use effects on soil microbiome composition and traits with consequences for its ecosystem carbon use efficiency

Cole, L., Goodall, T., Jehmlich, N., Griffiths, R. I., Gleixner, G., Gubry-Rangin, C. & Malik, A., 9 Apr 2024, bioRxiv, 22 p.

Research output: Working paper › Preprint

Open Access

Measurement of double-differential cross sections for mesonless charged-current muon neutrino interactions on argon with final-state protons using the MicroBooNE detector

collaboration, M., Abratenko, P., Alterkait, O., Aldana, D. A., Arellano, L., Asaadi, J., Ashkenazi, A., Balasubramanian, S., Baller, B., Barr, G., Barrow, D., Barrow, J., Basque, V., Rodrigues, O. B., Berkman, S., Bhanderi, A., Bhat, A., Bhattacharya, M., Bishai, M. & Blake, A. & 168 others, Bogart, B., Bolton, T., Book, J. Y., Brunetti, M. B., Camilleri, L., Cao, Y., Caratelli, D., Cavanna, F., Cerati, G., Chappell, A., Chen, Y., Conrad, J. M., Convery, M., Cooper-Troendle, L., Crespo-Anadon, J. I., Cross, R., Tutto, M. D., Dennis, S. R., Detje, P., Devitt, A., Diurba, R., Djurcic, Z., Dorrill, R., Duffy, K., Dytman, S., Eberly, B., Englezos, P., Ereditato, A., Evans, J. J., Fine, R., Fleming, B. T., Foreman, W., Franco, D., Furmanski, A. P., Gao, F., Garcia-Gamez, D., Gardiner, S., Ge, G., Gollapinni, S., Gramellini, E., Green, P., Greenlee, H., Gu, L., Gu, W., Guenette, R., Guzowski, P., Hagaman, L., Hen, O., Hilgenberg, C., Horton-Smith, G. A., Imani, Z., Irwin, B., Ismail, M. S., James, C., Ji, X., Jo, J. H., Johnson, R. A., Jwa, Y. J., Kalra, D., Kamp, N., Karagiorgi, G., Ketchum, W., Kirby, M., Kobilarcik, T., Kreslo, I., Lane, N., Lepetic, I., Li, J.-Y., Li, Y., Lin, K., Littlejohn, B. R., Liu, H., Louis, W. C., Luo, X., Mariani, C., Marsden, D., Marshall, J., Martinez, N., Caicedo, D. A. M., Martynenko, S., Mastbaum, A., Mawby, I., McConkey, N., Meddage, V., Mendez, J., Micallef, J., Miller, K., Mistry, K., Mohayai, T., Mogan, A., Mooney, M., Moor, A. F., Moore, C. D., Lepin, L. M., Moudgalya, M. M., Babu, S. M., Naples, D., Navrer-Agasson, A., Nayak, N., Nebot-Guinot, M., Nowak, J., Oza, N., Palamara, O., Pallat, N., Paolone, V., Papadopoulou, A., Papavassiliou, V., Parkinson, H., Pate, S. F., Patel, N., Pavlovic, Z., Piasetzky, E., Pletcher, K., Pophale, I., Qian, X., Raaf, J. L., Radeka, V., Rafique, A., Reggiani-Guzzo, M., Ren, L., Rochester, L., Rondon, J. R., Rosenberg, M., Ross-Lonergan, M., Safa, I., Scanavini, G., Schmitz, D. W., Schukraft, A., Seligman, W., Shaevitz, M. H., Sharankova, R., Shi, J., Snider, E. L., Soderberg, M., Soldner-Rembold, S., Spitz, J., Stancari, M., John, J. S., Strauss, T., Szelc, A. M., Tang, W., Taniuchi, N., Terao, K., Thorpe, C., Torbunov, D., Totani, D., Toups, M., Trettin, A., Tsai, Y.-T., Tyler, J., Uchida, M. A., Usher, T., Viren, B., Weber, M., Wei, H., White, A. J., Wolbers, S., Wongjirad, T., Wospakrik, M., Wresilo, K., Wu, W., Yandel, E., Yang, T., Yates, L. E., Yu, H. W., Zeller, G. P., Zennamo, J. & Zhang, C., 28 Mar 2024.

Research output: Working paper › Preprint

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A survey of experts to identify methods to detect problematic studies: Stage 1 of the INSPECT-SR Project

Wilkinson, J., Heal, C., Antoniou, G. A., Flemyng, E., Avenell, A., Barbour, V., Bordewijk, E. M., Brown, N. J. L., Clarke, M., Dumville, J., Grohmann, S., Gurrin, L. C., Hayden, J. A., Hunter, K. E., Lam, E., Lasserson, T., Li, T., Lensen, S., Liu, J. & Lundh, A. & 12 others, Meyerowitz-Katz, G., Mol, B. W., O'Connell, N. E., Parker, L., Redman, B., Seidler, A. L., Sheldrick, K., Sydenham, E., Dahly, D. L., van Wely, M., Bero, L. & Kirkham, J. J., 25 Mar 2024, MedRxiv.

Research output: Working paper › Preprint

Open Access

Downregulation of NR4A3 During Inactivity Alters Glucose Metabolism and Impairs Translation in Human Skeletal Muscle

Smith, J. A. B., Gabriel, B., Krook, A., Zierath, J. R. & Pillon, N. J. (Corresponding Author), 13 Mar 2024, bioRxiv, 21 p.

Research output: Working paper › Preprint

Open Access

Hydroxysteroid 17-beta dehydrogenase 13(Hsd17b13)knockdown attenuates liver steatosis in high-fat diet obese mice

Mahmood, S., Morrice, N., Thompson, D., Milanizadeh, S., Wilson, S., Whitfield, P. D., Mcilroy, G. D., Rochford, J. J. & Mody, N., 1 Mar 2024, bioRxiv.

Research output: Working paper › Preprint

Open Access

Consequential sound induces illusory distortions in the perception and prediction of robot motion

Currie, J., Giannaccini, M. E. & Bach, P., 17 Feb 2024, OSF, 22 p.

Research output: Working paper › Preprint

Open Access

2023

Synaptic interactions between stellate cells and parvalbumin interneurons in layer 2 of the medial entorhinal cortex are organized at the scale of grid cell clusters

Huang, L.-W., Garden, D., McClure, C. & Nolan, M., 21 Dec 2023, eLife Sciences Publications.

Research output: Working paper › Preprint

Eating Disorder and Autism Collaborative (EDAC) Project Outline: Promoting eating disorder research embedded in a neurodiversity-affirming culture.

Duffy, F., Gillespie-Smith, K., Sharpe, H., Buchan, K., Nimbley, E., Maloney, E., Sader, M., Kettley, S., Kerr-Gaffney, J., Waiter, G. & Tchanturia, K., 6 Dec 2023, OSF, 15 p. (Open Science Framework Preprints).

Research output: Working paper › Preprint

Open Access

Milo2.0 unlocks population genetic analyses of cell state abundance using a count-based mixed model

Alice, K., Marioni, J. C. & Morgan, M. D., 11 Nov 2023, bioRxiv.

Research output: Working paper › Preprint

Open Access

Butyrate-producing bacteria as probiotic supplement: beneficial effects on metabolism and modulation of behavior in an obesity mouse model

Garcia-Serrano, A. M., Skoug, C., Axling, U., Korhonen, E. R., Teixeira, C., Ahrén, I. L., Mukhopadhya, I., Boteva, N., Martin, J., Scott, K., Gratz, S., Stenkula, K. G., Holm, C. & Duarte, J. M. N., 4 Nov 2023, bioRxiv.

Research output: Working paper › Preprint

Open Access

Repurposing an Offshore Oil and Gas Platform for Green Hydrogen Production: A North Sea Case Study

Wilcox, L., Wiranegara, N., Martinez-Felipe, A. & Hastings, A. (Corresponding Author), 3 Nov 2023, SSRN, 20 p. (SSRN).

Research output: Working paper › Preprint

Open Access

RNA aptamer reveals nuclear TDP-43 pathology is an early aggregation event that coincides withSTMN-2cryptic splicing and precedes clinical manifestation in ALS

Spence, H., Waldron, F. M., Saleeb, R. S., Brown, A.-L., Rifai, O. M., Gilodi, M., Read, F., Roberts, K., Milne, G., Wilkinson, D., O’Shaughnessy, J., Pastore, A., Fratta, P., Shneider, N., Tartaglia, G. G., Zacco, E., Horrocks, M. H. & Gregory, J. M., 27 Oct 2023, bioRxiv.

Research output: Working paper › Preprint

Open Access

Mesenchymal-specific Alms1 knockout in mice recapitulates key metabolic features of Alström Syndrome

McKay, E. J., Luijten, I., Weng, X., Martinez de Morentin, P. B., Gao, Z., Kolonin, M. G., Heisler, L. K., Semple, R. K. (Corresponding Author) & De Frutos González, E., 13 Oct 2023, bioRxiv, 31 p. (bioRxiv).

Research output: Working paper › Preprint

Open Access

Protocol for the development of a tool (INSPECT-SR) to identify problematic randomised controlled trials in systematic reviews of health interventions

Wilkinson, J. (Corresponding Author), Heal, C., Antoniou, G. A., Flemyng, E., Alfirevic, Z., Avenell, A., Barbour, V., Brown, N. J. L., Carlisle, J., Clarke, M., Dicker, P., Dumville, J., Grey, A., Gurrin, L. C., Hayden, J. A., Heathers, J., Hunter, K. E., Lasserson, T., Lensen, S. & Li, T. & 17 others, Li, W., Loder, E., Lundh, A., Meyerowitz-Katz, G., Mol, B. W., O' Connell, N. E., Parker, L., Redman, B. K., Seidler, A. L., Sheldrick, K. A., Sydenham, E., Torgerson, D. J., van Wely, M., Wang, R., Bero, L., Kirkham, J. J. & Lam, E., 10 Oct 2023, MedRxiv, 16 p.

Research output: Working paper › Preprint

Open Access

The contribution of early language exposure to the cortical tracking of speech

Pérez-Navarro, J., Klimovich-Gray, A., Lizarazu, M., Piazza, G., Molinaro, N. & Lallier, M., 14 Sept 2023, bioRxiv.

Research output: Working paper › Preprint

Open Access

Morning exercise and pre-breakfast metformin interact to reduce glycaemia in people with Type 2 Diabetes: a randomized crossover trial

Gabriel, B. (Corresponding Author), Peña Carrillo, B. J., Cope, E., Gurel, S., Traslosheros, A., Kenny, A., Mody, N., Delibegovic, M., Philip, S., Thies, F. & Blana, D., 7 Sept 2023, MedRxiv, 19 p. (medRxiv : the preprint server for health sciences).

Research output: Working paper › Preprint

A Digital Tool for Clinical Evidence-Driven Guideline Development: Studying Properties of Trial Eligible and Ineligible Populations

Mumtaz, S., McMinn, M., Cole, C., Gao, C., Hall, C., Guignard-Duff, M., Huang, H., McAllister, D. A., Morales, D. R., Jefferson, E. & Guthrie, B., 1 Sept 2023, JMIR Publications Inc.

Research output: Working paper › Preprint

Open Access

Associations between sex, systemic iron and inflammatory status and subcortical brain iron

Spence, H., Mengoa-Fleming, S., Sneddon, A. A., McNeil, C. J. & Waiter, G. D., 22 Aug 2023, bioRxiv.

Research output: Working paper › Preprint

Open Access

Allergen-induced airway matrix remodelling in mice can be prevented or reversed by targeting chitinase-like proteins

Parkinson, J. E., Adamson, A., MacDonald, A. S., Allen, J. E. & Sutherland, T. E., 21 Aug 2023, bioRxiv.

Research output: Working paper › Preprint

Open Access

Updating estimates of Plasmodium knowlesi malaria risk in response to changing land use patterns across Southeast Asia.

Tobin, R. J., Harrison, L. E., Tully, M. K., Lubis, I. N. D., Noviyanti, R., Anstey, N. M., Rajahram, G. S., Grigg, M. J., Flegg, J. A., Price, D. J. & Shearer, F. M., 8 Aug 2023, (E-pub ahead of print) MedRxiv.

Research output: Working paper › Preprint

Open Access

Maternal adaptations in mouse lactation are vulnerable to diet-induced excess adiposity

Breznik, J. A., Ribeiro, T. A., Yeo, E., Kennelly, B. K. E., Wang, X., Quin, C., Cowbrough, B., Verdú, E. F., Bowdish, D. M. E. & Sloboda, D. M., 23 Jul 2023, bioRxiv, 66 p.

Research output: Working paper › Preprint

Open Access

A review of scientific theories used to justify the delivery of school-based mindfulness programmes . A protocol for a scoping review

Abbott, P. (Corresponding Author), Nixon, G., Stanley, I. & D’Ambruoso, L., 20 Jun 2023, MedRxiv, 14 p.

Research output: Working paper › Preprint

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Study protocol for a Critical Realist pilot cluster-randomised controlled trial of a whole-school-based mindfulness intervention (SBMI) promoting child and adolescent mental wellbeing in Rwanda and Ethiopia

Abbott, P., D’Ambruoso, L., Yared, M., McNamee, P., Hailu, T. & Nzabalirwa, W., 11 May 2023, MedRxiv, 32 p. (medRxiv).

Research output: Working paper › Preprint

Open Access

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A brainstem to hypothalamic arcuate nucleus GABAergic circuit drives feeding

Martinez de Morentin, P. B., Gonzalez, J. A., Dowsett, G. K. C., Martynova, Y., Yeo, G. S. H., Sylantyev, S. & Heisler, L. K., 3 May 2023, bioRxiv.

Research output: Working paper › Preprint

Open Access

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Infection and Social Dislocation: Wellbeing Impacts of COVID-19 on Children and Young People - Perspectives of Rwandan Leaders

Abbott, P., Bingwaho, A., Cowan, E. & D'Ambruoso, L., 28 Mar 2023, (Accepted/In press) MDPI AG, 15 p.

Research output: Working paper › Preprint

Open Access

Wnt signalling, cell fate determination and anteroposterior polarity of the skate gill arch skeleton

Rees, J., Sleight, V., Clark, S. J., Nakamura, T. & Gillis, J. A., 20 Mar 2023, bioRxiv.

Research output: Working paper › Preprint

Open Access

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Identifying Long Covid Using Electronic Health Records: A National Observational Cohort Study in Scotland

Jeffrey, K., Woolford, L., Maini, R., Basetti, S., Batchelor, A., Weatherill, D., White, C., Hammersley, V., Millington, T., Macdonald, C., Quint, J. K., Kerr, R., Kerr, S., Shah, S. A., Fagbamigbe, A., Colin, S., Katikireddi, S. V., Robertson, C., Ritchie, L. D. & Sheikh, A. & 1 others, Daines , L., 7 Mar 2023, SSRN, 24 p.

Research output: Working paper › Preprint

Ectodermal Wnt signalling, cell fate determination and polarity of the skate gill arch skeleton

Rees, J. M., Sleight, V. A., Clark, S. J., Nakamura, T. & Gillis, J. A., 6 Mar 2023, bioRxiv.

Research output: Working paper › Preprint

Open Access

Distinct neuroinflammatory signatures exist across genetic and sporadic ALS cohorts

Rifai, O. M., O'shaughnessy, J., Dando, O., Munro, A. F., Sewell, M. D. E., Abrahams, S., Waldron, F., Sibley, C. R. & Gregory, J., 20 Jan 2023, bioRxiv.

Research output: Working paper › Preprint

Open Access

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Expanding Community Health Worker decision space: impacts of a Participatory Action Research training intervention in a rural South African district

Abruquah, N., Witter, S., Mabetha, D., Van Der Merwe, M., Goosen, G., Sigudla, J. & D'Ambruoso, L., 6 Jan 2023, (Submitted) Research Square.

Research output: Working paper › Preprint

2022

Aberrant miR-29 is a predictive feature of severe phenotypes in pediatric Crohn’s disease

Shumway, A., Shanahan, M. T., Hollville, E., Chen, K., Beasley, C., Villanueva, J. W., Albert, S., Lian, G., Cure, M. R., Schaner, M., Zhu, L.-C., Bantumilli, S., Deshmukh, M., Furey, T. S., Sheikh, S. Z. & Sethupathy, P., 19 Dec 2022, bioRxiv.

Research output: Working paper › Preprint

Open Access

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Inequalities in children's mental health care: analysis of routinely collected data on prescribing and referrals to secondary care

Ball, W., Black, C., Gordon, S., Ostrovska, B., Paranjothy, S., Rasalam, A., David, R., Rowlands, H., Rzewuska, M., Thompson, E., Wilde, K. & Butler, J. (Corresponding Author), 24 Oct 2022, MedRxiv, 32 p.

Research output: Working paper › Preprint

BayesGmed: An R-package for Bayesian Causal Mediation Analysis

Yimer, B. B. (Corresponding Author), Lunt, M., Beasley, M., Macfarlane, G. J. & McBeth, J., 16 Oct 2022, ArXiv, p. 1-20, 20 p.

Research output: Working paper › Preprint

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The time course of social and non-social implicit Sense of Agency

Silver, C. A. (Corresponding Author), Tatler, B., Chakravarthi, R. & Timmermans, B., 23 Sept 2022, Research Square, 35 p.

Research output: Working paper › Preprint

Open Access

Teleworking and Housing Demand

Schulz, R., Watson, V. & Wersing, M., 2 Sept 2022, SSRN, 46 p. (RSUE-D-22-00227).

Research output: Working paper › Preprint

Open Access

Teleworking and Housing Demand

Schulz, R., Watson, V. & Wersing, M., 2 Sept 2022, SSRN.

Research output: Working paper › Preprint

Open Access

A Systematic Approach to Identify Neuroprotective Interventions for Motor Neuron Disease

Wong, C., Gregory, J., Liao, J., Egan, K., Vesterinen, H. M., Khan, A. A., Anwar, M., Beagan, C., Brown, F., Cafferkey, J., Cardinali, A., Chiam, J. Y., Chiang, C., Collins, V., Dormido, J., Elliott, E., Foley, P., Foo, Y. C., Fulton-Humble, L. & Gane, A. B. & 30 others, Glasmacher, S., Heffernan, Á., Jayaprakash, K., Jayasuriya, N., Kaddouri, A., Kiernan, J., Langlands, G., Leighton, D., Liu, J., Lyon, J., Mehta, A. R., Meng, A., Nguyen, V., Park, K. H., Quigley, S., Rashid, Y., Salzinger, A., Shiell, B., Singh, A., Soane, T., Thompson, A., Tomala, O., Waldron, F. M., Selvaraj, B. T., Chataway, J., Swingler, R., Connick, P., Pal, S., Chandran, S. & Macleod, M. R. (Corresponding Author), 22 Apr 2022, MedRxiv.

Research output: Working paper › Preprint

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A proxy of subsurface Chlorophyll-a in shelf waters: use of density profiles and the below mixed layer depth (BMLD)

Zampollo, A. (Corresponding Author), Cornulier, T., O'Hara Murray, R., Tweddle, J., Dunning, J. & Scott, B., 14 Apr 2022, EGU, 37 p.

Research output: Working paper › Preprint

Open Access

Utility Functions for Human/Robot Interaction

Yun, B., Oren, N. & Croitoru, M., 8 Apr 2022, ArXiv, 7 p.

Research output: Working paper › Preprint

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Using National Electronic Health Records for Pandemic Preparedness: Validation of a Parsimonious Model for Predicting Excess Deaths Among Those With COVID-19

Mizani, M. A., Dashtban, M., Pasea, L., Lai, A., Thygesen, J. H., Tomlinson, C., Handy, A., Mamza, J. B., Morris, T., Khalid, S., Zaccardi, F., Macleod, M., Torabi, F., Canoy, D., Akbari, A., Berry, C., Bolton, T., Nolan, J. M., Khunti, K. & Denaxas, S. & 4 others, Hemingway, H., Sudlow, C., Banerjee, A. (Corresponding Author) & CVD-COVID-UK Consortium, 25 Mar 2022, SSRN, 20 p. (SSRN)(Preprints with THE LANCET).

Research output: Working paper › Preprint

Open Access

The little skate genome and the evolutionary emergence of wing-like fin appendages

Marletaz, F., Calle-Mustienes, E. D. L., Acemel, R. D., Nakamura, T., Paliou, C., Naranjo, S., Martinez-Garcia, P. M., Cases, I., Sleight, V. A., Hirschberger, C., Marcet-Houben, M., Navon, D., Andrescavage, A., Skvortsova, K., Duckett, P. E., Gonzalez-Rajal, A., Bogdanovic, O., Gibcus, J. H., Yang, L. & Gallardo-Fuentes, L. & 11 others, Sospedra, I., Lopez-Rios, J., Darbellay, F., Visel, A., Dekker, J., Shubin, N., Gabaldon, T., Tena, J. J., Lupianez, D. G., Rokhsar, D. S. (Corresponding Author) & Gomez-Skarmeta, J. L., 22 Mar 2022, bioRxiv, 49 p.

Research output: Working paper › Preprint

Open Access

pTDP-43 aggregates accumulate in the gut and other non-central nervous system tissues prior to symptom onset in amyotrophic lateral sclerosis

Pattle, S. B., O'shaughnessy, J., Rifai, O. M., Pate, J., Arends, M. J., Waldron, F. & Gregory, J. (Corresponding Author), 19 Mar 2022, bioRxiv, 19 p.

Research output: Working paper › Preprint

Open Access